Cells which might be poor in homologous recombination, resembling people who lack useful breast cancer-associated 1 (BRCA1) or BRCA2, are hypersensitive to inhibition of poly(ADP-ribose) polymerase (PARP). Nevertheless, BRCA-deficient tumors symbolize solely a small fraction of grownup cancers, which could Read more…
- Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.
- Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.
- An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.
- Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.
- Targeted therapy for cancer using PARP inhibitors.
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