Repair DNA With Parp Inhibitors
Parp inhibitor is an abbreviation for poly ADP ribose polymerase inhibitors. A Parp inhibitor belongs to a group of pharmacological inhibitors. The enzyme/drug Parp Inhibitor is an extremely useful element in treating many diseases. Parp inhibitors are currently being studied to see their potential for curing cancer.
All the treatments required for cancer are more dependent on parp than on the ordinary cells. Chemotherapeutic cancer therapy mainly targets parp inhibitors in the therapy. Parp inhibitors are also useful in treating life taking diseases. The diseases such as a stroke and myocardial infarction can be cured best with Parp inhibitors.
Moreover, long term neurodegenerative diseases are also best medicated with a Parp inhibitor. A Parp inhibitor is very effective in repairing DNA. DNA gets damaged several times during cell cycles. Repairing damaged DNA is very essential.
Parp Inhibitor Proteins Restore DNA
The two most important proteins that help repairing DNA are BRCA1 and BRCA2. The proteins restore DNA by the error free homologous recombination repair or HRR pathway. When the gene for BRCA1 or BRCA2 is transformed, it leads to breast cancer. The change in proteins ceases or brings errors in the repairing of DNA causing hazardous disease.
When the change in gene gets much damaged it may also cause the death of many cells in the body. Parp 1 protein is effective in treating single stranded DNA. If the single stranded DNA breaks persist in the body unrepaired, then it may lead to double stranded DNA breaks.
The mutations in the proteins BRCA1 and BRCA2 cause tumors. The mutations caused in proteins leads to slowdown the effect of parp 1. Due to the deficiency of BRCA1 and BRCA2 the DNA cannot be repaired efficiently and leads to death of the cells. Ordinary cells do not reproduce their DNA like the cancer cells.
Normal cells have homologous repair operating that helps to survive the slowdown of Parp. A Cancer cell found in fast growing tumors is more responsive to parp inhibitors. The breast cancer therapies involvinf parp inhibitors help to reduce parp and repairs damaged DNA.