The Science Behind Parp
Poly polymerase shortly known as Parp is a nuclear enzyme that helps to repair damaged DNA in the human body. Parp normalizes the machinery that helps in restoring the damaged DNA. If the DNA, in the body is left unrepaired then it may cause death of the cells and also damage the cell cycle.
Normally, the healing of DNA is beneficial to the human body as it helps growth of healthy cells. The patients with cancer cells are required to repair the DNA with the help of parp as it is advantageous to them. Parp 1 activity is highly regulated among the cancer patients. Parp 1 plays a crucial role in survival and explosion of cancer cells.
Parp as a Capable Target
The slowdown of parp shows significant opposing tumor effects in numerous cancers. The activity of parp inhibitors emerges as stable for the non cancerous patients. Parp inhibition hence helps in reduction of growth of tumor cells in the human body. Moreover, the intake of parp inhibitors does not damage the normal cells in the body. In addition, the parp inhibitors also takes care that there is no side effect on the patient’s body.
Chemotherapy and Parp Inhibitors
Chemotherapy is the best cure found for the cancer patients till now. Chemotherapy uses alkylating agents and platinum drugs to help damage DNA from reproducing the cancer cells in the body. Iniparib, the Parp inhibitor, stops cancer cells from repairing their own DNA.
Parp inhibitors help in treating certain cancers in a different manner. Inhibition of parp leads to breakdown of single stranded DNA, which in turn causes double stranded DNA breaks in the body. The effect of parp inhibitor in double stranded DNA break ultimately leads to the death of cancer cells.