PARP inhibitors are being developed as therapeutic brokers for most cancers. Greater than six compounds have entered scientific trials. The vast majority of these compounds are β-nicotinamide adenine dinucleotide (NAD(+))-competitive inhibitors. One exception is iniparib, which has been proposed to be a noncompetitive PARP inhibitor. On this research, we evaluate the biologic actions of two completely different structural lessons of NAD(+)-competitive compounds with iniparib and its C-nitroso metabolite. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells, and the first mechanism of motion for iniparib is probably going not by way of inhibition of PARP exercise.
Two chemical sequence of NAD(+)-competitive PARP inhibitors, iniparib and its C-nitroso metabolite, had been analyzed in enzymatic and mobile assays. Viability assays had been carried out in MDA-MB-436 (BRCA1-deficient) and DLD1(-/-) (BRCA2-deficient) cells along with BRCA-proficient MDA-MB-231 and DLD1(+/+) cells. Capan-1 and B16F10 xenograft fashions had been used to check iniparib and veliparib in vivo. Mass spectrometry and the (3)H-labeling methodology had been used to watch the covalent modification of proteins.
All NAD(+)-competitive inhibitors present sturdy exercise in a PARP mobile assay, strongly potentiate the exercise of temozolomide, and elicit sturdy cell killing in BRCA-deficient tumor cells in vitro and in vivo. Cell killing was related to an induction of DNA injury. In distinction, neither iniparib nor its C-nitroso metabolite inhibited PARP enzymatic or mobile exercise, potentiated temozolomide, or confirmed exercise in a BRCA-deficient setting. We discover that the nitroso metabolite of iniparib types adducts with many cysteine-containing proteins. Moreover, each iniparib and its nitroso metabolite type protein adducts nonspecifically in tumor cells.
To ensure that PARP inhibitors to enhance outcomes for sufferers, their sensitizing results have to be tumour particular. Early scientific knowledge point out that systemic toxicity could also be exacerbated, so future trials should deal with this challenge. The mechanism of motion of PARP inhibitors together with cytotoxic brokers can also be unsure. Amongst BRCA-deficient cancers, mechanisms of inherent and purchased resistance to PARP inhibitors are below investigation. Combining these brokers with radiotherapy seems promising however designing scientific trials to check the efficacy and toxicity of this mixture is problematic.
PARP inhibitors for BRCA1/2-mutated and sporadic ovarian most cancers: present follow and future instructions.
Poly(ADP-ribose) polymerase (PARP) inhibitors trigger focused tumour cell loss of life in homologous recombination (HR)-deficient cancers, together with BRCA-mutated tumours, by exploiting artificial lethality. PARP inhibitors are being evaluated in late-stage scientific trials of ovarian most cancers (OC). Just lately, olaparib was the primary PARP inhibitor accepted within the European Union and United States for the therapy of superior BRCA-mutated OC. This paper opinions the position of BRCA mutations for tumorigenesis and PARP inhibitor sensitivity, and summarises the scientific growth of PARP inhibitors for the therapy of sufferers identified with OC.
Among the many 5 key PARP inhibitors at the moment in scientific growth, olaparib has undergone probably the most intensive scientific investigation. PARP inhibitors have demonstrated sturdy antitumour exercise in BRCA-mutated superior OC as a single agent within the therapy and upkeep setting, significantly in platinum-sensitive illness. PARP inhibitors are nicely tolerated; nevertheless, additional cautious evaluation of average and late-onset toxicity is obligatory within the upkeep and adjuvant setting, respectively. PARP inhibitors are additionally being evaluated together with chemotherapeutic and novel focused brokers to potentiate antitumour actions.
Present analysis is extending using PARP inhibitors past BRCA mutations to different sensitising molecular defects that end in HR-deficient most cancers, and is defining an HR-deficiency signature. Trials are underway to find out whether or not such a signature will predict sensitivity to PARP inhibitors in girls with sporadic OC. In vitro talazoparib potentiated the toxicity of temozolomide as much as 85-fold, with marked potentiation in Ewing sarcoma and leukemia strains (30-50-fold). There was much less potentiation for topotecan. In vivo, talazoparib potentiated the toxicity of temozolomide, and mixture A and mixture B characterize the MTDs when mixed with low-dose or high-dose talazoparib, respectively.
Each mixtures demonstrated vital synergism in opposition to 5 of 10 Ewing sarcoma xenografts. The mix demonstrated modest exercise in opposition to most different xenograft fashions. Pharmacodynamic research confirmed a treatment-induced full lack of PARP solely in tumor fashions delicate to both talazoparib alone or talazoparib plus temozolomide. These analyses present predictive, prognostic, response, and resistance knowledge with “second hit” mutations first detectable at illness development, suggesting clonal evolution from treatment-selective strain and platinum resistance.
Circulating Cell-Free DNA to Information Prostate Most cancers Therapy with PARP Inhibition.
Biomarkers for extra exact affected person care are wanted in metastatic prostate most cancers. We’ve reported a part II trial (TOPARP-A) of the PARP inhibitor olaparib in metastatic prostate most cancers, demonstrating antitumor exercise associating with homologous recombination DNA restore defects. We now report focused and whole-exome sequencing of serial circulating cell-free DNA (cfDNA) samples collected throughout this trial. Decreases in cfDNA focus independently related to consequence in multivariable analyses.
 ELISA Kit) Human Poly ADP Ribose Polymerase (PARP) ELISA Kit |
|
RD-PARP-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 478 |
Human Poly ADP Ribose Polymerase (PARP) ELISA Kit |
|
RD-PARP-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 662 |
Human Poly ADP Ribose Polymerase (PARP) ELISA Kit |
|
DLR-PARP-Hu-48T |
DL Develop |
48T |
EUR 479 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase (PARP) in samples from tissue homogenates, cell lysates or other biological fluids. |
Human Poly ADP Ribose Polymerase (PARP) ELISA Kit |
|
DLR-PARP-Hu-96T |
DL Develop |
96T |
EUR 621 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase (PARP) in samples from tissue homogenates, cell lysates or other biological fluids. |
) Anti-PARP (3G4) |
|
YF-MA10018 |
Abfrontier |
100 ug |
EUR 363 |
|
Description: Mouse monoclonal to PARP |
) Anti-PARP (2C7) |
|
YF-MA11839 |
Abfrontier |
50 ug |
EUR 363 |
|
Description: Mouse monoclonal to PARP |
) anti-PARP (M3) |
|
LF-MA20421 |
Abfrontier |
100 ug |
EUR 354 |
|
Description: Mouse monoclonal to PARP |
) anti-PARP (7A10) |
|
LF-MA30362 |
Abfrontier |
100 ul |
EUR 486 |
|
Description: Mouse Monoclonal to PARP |
 Anti-PARP antibody |
|
STJ97033 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Mouse monoclonal to PARP. |
 Rabbit Polyclonal antibody Anti-CRBN |
|
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349 |
) anti-Cleaved PARP (M4) |
|
LF-MA20422 |
Abfrontier |
100 ug |
EUR 354 |
|
Description: Mouse monoclonal to Cleaved PARP |
 Anti-PARP/PARP1 Antibody |
|
PA2227 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-PARP/PARP1 Antibody |
|
PB9309 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-PARP-1 Antibody |
|
A00122-1 |
BosterBio |
100ul |
EUR 397 |
|
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse. |
 Anti-PARP-2 Antibody |
|
A03270-1 |
BosterBio |
100ul |
EUR 397 |
|
Description: Rabbit Polyclonal Antibody for PARP-2 Antibody (PARP2) detection. Tested with WB in Human, Mouse. |
 Anti-PARP-3 Antibody |
|
A03762 |
BosterBio |
100ul |
EUR 522 |
|
Description: Rabbit Polyclonal PARP-3 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse. |
 Anti-PARP-2 antibody |
|
STJ94959 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to PARP-2. |
 Anti-PARP-3 antibody |
|
STJ94960 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to PARP-3. |
 Anti-PARP-4 antibody |
|
STJ94961 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to PARP-4. |
 Anti-Cleaved PARP antibody |
|
STJ97034 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Mouse monoclonal to Cleaved PARP. |
Anti-Cleaved PARP antibody |
|
STJ97047 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Cleaved-PARP-1 is a protein encoded by the PARP1 gene which is approximately 113 kDa. Cleaved-PARP-1 is localised to the nucleus. It is involved in telomere C-strand synthesis, transcription-coupled nucleotide excision repair and survival caspase cascades. It is a chromatin-associated enzyme, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is DNA dependent and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation. It also pays a role in the regulation of the molecular events involved in the recovery of cell from DNA damage. Cleaved-PARP-1 is expressed in the nervous system, liver, intestine, lung and eye. Mutations in the PARP1 gene may result in diphtheria and hemorrhagic cystitis. The antibody STJ97047 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels Cleaved-PARP-1. |
 Anti-PARP-1 antibody |
|
STJ97648 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to PARP-1. |
 Anti-PARP Rabbit Monoclonal Antibody |
|
M00122 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Rabbit Monoclonal PARP Antibody. Validated in IF, IHC, ICC, WB and tested in Human, Mouse, Rat. |
Anti-PARP Rabbit Monoclonal Antibody |
|
M00122-3 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Rabbit Monoclonal PARP Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
) Anti-PARP-1 antibody (KLH) |
|
STJ98308 |
St John's Laboratory |
100 µl |
EUR 234 |
|
Description: Mouse monoclonal to PARP-1 (KLH). |
 Mouse PARP ELISA Kit |
|
EMP0031 |
Abclonal |
96Tests |
EUR 521 |
 PARP Mouse Monoclonal Antibody |
|
38067-100ul |
SAB |
100ul |
EUR 252 |
PARP Mouse Monoclonal Antibody |
|
38067-50ul |
SAB |
50ul |
EUR 187 |
 PARP antibody |
|
BF0719 |
Affbiotech |
200ul |
EUR 376 |
|
Description: PARP mouse monoclonal antibody detects endogenous levels of total PPAR. |
PARP antibody |
|
20R-1423 |
Fitzgerald |
100 ug |
EUR 673 |
|
Description: Rabbit polyclonal PARP antibody |
PARP antibody |
|
70R-11555 |
Fitzgerald |
100 ug |
EUR 404 |
|
Description: Rabbit polyclonal PARP antibody |
PARP antibody |
|
70R-11640 |
Fitzgerald |
100 ug |
EUR 611 |
|
Description: Rabbit polyclonal PARP antibody |
PARP antibody |
|
70R-11641 |
Fitzgerald |
100 ug |
EUR 581 |
|
Description: Rabbit polyclonal PARP antibody |
PARP antibody |
|
70R-30801 |
Fitzgerald |
100 ug |
EUR 327 |
|
Description: Rabbit polyclonal PARP antibody |
PARP antibody |
|
70R-30803 |
Fitzgerald |
100 ug |
EUR 327 |
|
Description: Rabbit polyclonal PARP antibody |
PARP antibody |
|
10R-2170 |
Fitzgerald |
100 ul |
EUR 403 |
|
Description: Mouse monoclonal PARP antibody |
PARP antibody |
|
10R-8001 |
Fitzgerald |
100 ul |
EUR 503 |
|
Description: Mouse monoclonal PARP antibody |
PARP antibody |
|
10R-8057 |
Fitzgerald |
100 ug |
EUR 470 |
|
Description: Mouse polyclonal PARP antibody |
 PARP Antibody |
|
48838-100ul |
SAB |
100ul |
EUR 333 |
PARP Antibody |
|
48838-50ul |
SAB |
50ul |
EUR 239 |
 Polyclonal Goat anti-GST α-form |
|
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 280 |
 Polyclonal Goat anti-GST μ-form |
|
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 280 |
 Polyclonal Goat anti-GST p-form |
|
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 280 |
 Anti-Cleaved PARP Rabbit Monoclonal Antibody |
|
M00122-1 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Rabbit Monoclonal Cleaved PARP Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat. |
Anti-Cleaved PARP Rabbit Monoclonal Antibody |
|
M00122-2 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Rabbit Monoclonal Cleaved PARP Antibody. Validated in Flow Cytometry, IP, IF, ICC, WB and tested in Human. |
 antibody) Anti-PARP-1 (Acetyl K521) antibody |
|
STJ98846 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to E2F-1. |
 antibody) Anti-Cleaved-PARP-1 (G215) antibody |
|
STJ90072 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Rabbit polyclonal to Cleaved-PARP-1 (G215). |
 antibody) Anti-Cleaved-PARP-1 (D214) antibody |
|
STJ90100 |
St John's Laboratory |
200 µl |
EUR 197 |
|
Description: Cleaved-PARP-1 is a protein encoded by the PARP1 gene which is approximately 113 kDa. Cleaved-PARP-1 is localised to the nucleus. It is involved in telomere C-strand synthesis, transcription-coupled nucleotide excision repair and survival caspase cascades. It is a chromatin-associated enzyme, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is DNA dependent and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation. It also pays a role in the regulation of the molecular events involved in the recovery of cell from DNA damage. Cleaved-PARP-1 is expressed in the nervous system, liver, intestine, lung and eye. Mutations in the PARP1 gene may result in diphtheria and hemorrhagic cystitis. The antibody STJ90100 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment activated PARP-1 protein resulting from cleavage adjacent to D214. |
 Cleaved PARP Mouse Monoclonal Antibody |
|
38068-100ul |
SAB |
100ul |
EUR 252 |
Cleaved PARP Mouse Monoclonal Antibody |
|
38068-50ul |
SAB |
50ul |
EUR 187 |
Cleaved PARP Mouse Monoclonal Antibody |
|
38076-100ul |
SAB |
100ul |
EUR 252 |
Cleaved PARP Mouse Monoclonal Antibody |
|
38076-50ul |
SAB |
50ul |
EUR 187 |
 Cleaved-PARP Antibody |
|
AF7023 |
Affbiotech |
200ul |
EUR 376 |
|
Description: PARP (Cleaved-Asp214) Antibody detects endogenous levels of fragment of activated PARP resulting from cleavage adjacent to Asp214. |
Cleaved-PARP Antibody |
|
BF9106 |
Affbiotech |
200ul |
EUR 376 |
|
Description: The Cleaved PARP Mouse mAb can recognize endogenous pro and active PARP proteins. |
 Antibody) PARP (Cleaved) Antibody |
|
3140-100 |
Biovision |
|
EUR 468 |
PARP (Cleaved) Antibody |
|
3141-100 |
Biovision |
|
EUR 446 |
 PARP Monoclonal Antibody |
|
EM1131-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Mouse Monoclonal antibody against PARP from Human. This antibody is tested and validated for WB, ELISA, IHC |
PARP Monoclonal Antibody |
|
EM1131-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Mouse Monoclonal antibody against PARP from Human. This antibody is tested and validated for WB, ELISA, IHC |
 Cleaved PARP Antibody |
|
abx020094-100ug |
Abbexa |
100 ug |
EUR 439 |
|
|
PARP Monoclonal Antibody |
|
ABM40131-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
PARP Monoclonal Antibody |
|
ABM40131-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
PARP Monoclonal Antibody |
|
ABM40131-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
 Polyclonal PARP Antibody |
|
APR08928G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PARP . This antibody is tested and proven to work in the following applications: |
 Cleaved-PARP antibody |
|
29033-100ul |
SAB |
100ul |
EUR 252 |
Cleaved PARP Antibody |
|
48805-100ul |
SAB |
100ul |
EUR 333 |
Cleaved PARP Antibody |
|
48805-50ul |
SAB |
50ul |
EUR 239 |
 Cleaved-PARP Blocking Peptide |
|
AF7023-BP |
Affbiotech |
1mg |
EUR 195 |
 PARP antibody Blocking Peptide |
|
BF0719-BP |
Affbiotech |
1mg |
EUR 195 |
Cleaved-PARP Blocking Peptide |
|
BF9106-BP |
Affbiotech |
1mg |
EUR 195 |
 PARP recombinant monoclonal antibody |
|
A5037 |
Bimake |
100ul X 3 |
EUR 595 |
|
|
|
Description: A recombinant monoclonal antibody from rabbit against human PARP for WB,ELISA |
) PARP Antibody (Clone 7A10) |
|
3023-100 |
Biovision |
|
EUR 403 |
) PARP Antibody (Clone 10H) |
|
3000-100 |
Biovision |
|
EUR 370 |
) PARP Antibody (Clone 839120) |
|
6659-100 |
Biovision |
|
EUR 403 |
) PARP Antibody (Clone 2B6) |
|
A1109-100 |
Biovision |
|
EUR 359 |
 PARP-1, human recombinant |
|
4992-50 |
Biovision |
|
EUR 425 |
 PARP-4 Polyclonal Antibody |
|
ES4835-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against PARP-4 from Human. This antibody is tested and validated for IHC, WB, ELISA |
PARP-4 Polyclonal Antibody |
|
ES4835-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against PARP-4 from Human. This antibody is tested and validated for IHC, WB, ELISA |
 PARP-1 Polyclonal Antibody |
|
ES8376-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against PARP-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
PARP-1 Polyclonal Antibody |
|
ES8376-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against PARP-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
 Sheep PARP ELISA Kit |
|
ESP0031 |
Abclonal |
96Tests |
EUR 521 |
 Cleaved PARP Monoclonal Antibody |
|
EM1132-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC |
Cleaved PARP Monoclonal Antibody |
|
EM1132-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC |
Cleaved PARP Monoclonal Antibody |
|
EM1145-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC |
Cleaved PARP Monoclonal Antibody |
|
EM1145-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC |
 Monkey PARP ELISA Kit |
|
EMKP0031 |
Abclonal |
96Tests |
EUR 521 |
 Porcine PARP ELISA Kit |
|
EPP0031 |
Abclonal |
96Tests |
EUR 521 |
 Rat PARP ELISA Kit |
|
ERP0031 |
Abclonal |
96Tests |
EUR 521 |
 Rabbit PARP ELISA Kit |
|
ERTP0031 |
Abclonal |
96Tests |
EUR 521 |
 PARP-2 Polyclonal Antibody |
|
ES4413-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against PARP-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
 PARP-3 Polyclonal Antibody |
|
ES4414-100ul |
ELK Biotech |
100ul |
EUR 279 |
|
Description: A Rabbit Polyclonal antibody against PARP-3 from Human. This antibody is tested and validated for IHC, WB, ELISA |
PARP-3 Polyclonal Antibody |
|
ES4414-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against PARP-3 from Human. This antibody is tested and validated for IHC, WB, ELISA |
PARP-2 Polyclonal Antibody |
|
ES4413-50ul |
ELK Biotech |
50ul |
EUR 207 |
|
Description: A Rabbit Polyclonal antibody against PARP-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
 Chicken PARP ELISA Kit |
|
ECKP0031 |
Abclonal |
96Tests |
EUR 521 |
 Canine PARP ELISA Kit |
|
ECP0031 |
Abclonal |
96Tests |
EUR 521 |
 Human PARP ELISA Kit |
|
EHP0031 |
Abclonal |
96Tests |
EUR 521 |
 Anserine PARP ELISA Kit |
|
EAP0031 |
Abclonal |
96Tests |
EUR 521 |
 Bovine PARP ELISA Kit |
|
EBP0031 |
Abclonal |
96Tests |
EUR 521 |
 Goat PARP ELISA Kit |
|
EGTP0031 |
Abclonal |
96Tests |
EUR 521 |
PARP-4 Polyclonal Antibody |
|
ABP53836-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of PARP-4 from Human. This PARP-4 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200 |
PARP-4 Polyclonal Antibody |
|
ABP53836-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of PARP-4 from Human. This PARP-4 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200 |
PARP-4 Polyclonal Antibody |
|
ABP53836-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of PARP-4 from Human. This PARP-4 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200 |
PARP-2 Polyclonal Antibody |
|
ABP53414-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of PARP-2 from Human, Mouse. This PARP-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200 |
PARP-2 Polyclonal Antibody |
|
ABP53414-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of PARP-2 from Human, Mouse. This PARP-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200 |
PARP-2 Polyclonal Antibody |
|
ABP53414-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of PARP-2 from Human, Mouse. This PARP-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200 |
PARP-3 Polyclonal Antibody |
|
ABP53415-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of PARP-3 from Human. This PARP-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90 |
PARP-3 Polyclonal Antibody |
|
ABP53415-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of PARP-3 from Human. This PARP-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90 |
PARP-3 Polyclonal Antibody |
|
ABP53415-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of PARP-3 from Human. This PARP-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90 |
 Antibody) PARP (Cleaved-Asp214) Antibody |
|
20-abx015613 |
Abbexa |
-
EUR 314.00
-
EUR 98.00
-
EUR 398.00
-
EUR 495.00
|
-
100 ug
-
10 ug
-
200 ug
-
300 µg
|
|
|
 Antibody) PARP (Cleaved-Gly215) Antibody |
|
20-abx015614 |
Abbexa |
-
EUR 314.00
-
EUR 98.00
-
EUR 398.00
-
EUR 495.00
|
-
100 ug
-
10 ug
-
200 ug
-
300 µg
|
|
|
Cleaved PARP Monoclonal Antibody |
|
ABM40132-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
Cleaved PARP Monoclonal Antibody |
|
ABM40132-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
Cleaved PARP Monoclonal Antibody |
|
ABM40132-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
Cleaved PARP Monoclonal Antibody |
|
ABM40145-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
Cleaved PARP Monoclonal Antibody |
|
ABM40145-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
Cleaved PARP Monoclonal Antibody |
|
ABM40145-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide |
PARP-1 Polyclonal Antibody |
|
ABP57383-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
|
|
Description: A polyclonal antibody for detection of PARP-1 from Human, Mouse, Rat. This PARP-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 |
PARP-1 Polyclonal Antibody |
|
ABP57383-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
|
|
Description: A polyclonal antibody for detection of PARP-1 from Human, Mouse, Rat. This PARP-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 |
PARP-1 Polyclonal Antibody |
|
ABP57383-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
|
|
Description: A polyclonal antibody for detection of PARP-1 from Human, Mouse, Rat. This PARP-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 |
 Monoclonal antibody for PARP |
|
SMC-259D |
Stressmarq |
0.1ml |
EUR 314 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is not conjugated. |
Monoclonal antibody for PARP |
|
SMC-259D-A390 |
Stressmarq |
0.1ml |
EUR 361 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 390. |
Monoclonal antibody for PARP |
|
SMC-259D-A488 |
Stressmarq |
0.1ml |
EUR 360 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 488. |
Monoclonal antibody for PARP |
|
SMC-259D-A565 |
Stressmarq |
0.1ml |
EUR 360 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 565. |
Monoclonal antibody for PARP |
|
SMC-259D-A594 |
Stressmarq |
0.1ml |
EUR 360 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 594. |
Monoclonal antibody for PARP |
|
SMC-259D-A633 |
Stressmarq |
0.1ml |
EUR 360 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 633. |
Monoclonal antibody for PARP |
|
SMC-259D-A655 |
Stressmarq |
0.1ml |
EUR 360 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 655. |
Monoclonal antibody for PARP |
|
SMC-259D-A680 |
Stressmarq |
0.1ml |
EUR 360 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 680. |
Monoclonal antibody for PARP |
|
SMC-259D-A700 |
Stressmarq |
0.1ml |
EUR 360 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 700. |
Monoclonal antibody for PARP |
|
SMC-259D-ALP |
Stressmarq |
0.1ml |
EUR 355 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Alkaline Phosphatase. |
Monoclonal antibody for PARP |
|
SMC-259D-APC |
Stressmarq |
0.1ml |
EUR 359 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with APC. |
Monoclonal antibody for PARP |
|
SMC-259D-APCCY7 |
Stressmarq |
0.1ml |
EUR 432 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with APC/Cy7. |
Monoclonal antibody for PARP |
|
SMC-259D-BI |
Stressmarq |
0.1ml |
EUR 357 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Biotin. |
Monoclonal antibody for PARP |
|
SMC-259D-DY350 |
Stressmarq |
0.1ml |
EUR 436 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 350. |
Monoclonal antibody for PARP |
|
SMC-259D-DY405 |
Stressmarq |
0.1ml |
EUR 412 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 405. |
Monoclonal antibody for PARP |
|
SMC-259D-DY488 |
Stressmarq |
0.1ml |
EUR 393 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 488. |
Monoclonal antibody for PARP |
|
SMC-259D-DY594 |
Stressmarq |
0.1ml |
EUR 397 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 594. |
Monoclonal antibody for PARP |
|
SMC-259D-DY633 |
Stressmarq |
0.1ml |
EUR 387 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 633. |
Monoclonal antibody for PARP |
|
SMC-259D-FITC |
Stressmarq |
0.1ml |
EUR 353 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with FITC. |
Monoclonal antibody for PARP |
|
SMC-259D-HRP |
Stressmarq |
0.1ml |
EUR 349 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with HRP. |
Monoclonal antibody for PARP |
|
SMC-259D-P594 |
Stressmarq |
0.1ml |
EUR 367 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with PE/ATTO 594. |
Monoclonal antibody for PARP |
|
SMC-259D-PCP |
Stressmarq |
0.1ml |
EUR 359 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with PerCP. |
Monoclonal antibody for PARP |
|
SMC-259D-RPE |
Stressmarq |
0.1ml |
EUR 358 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with RPE. |
Monoclonal antibody for PARP |
|
SMC-259D-STR |
Stressmarq |
0.1ml |
EUR 359 |
|
|
|
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Streptavidin. |
 Antibody) Polyclonal PARP (Cleaved) Antibody |
|
APR08927G |
Leading Biology |
0.1mg |
EUR 528 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PARP (Cleaved) . This antibody is tested and proven to work in the following applications: |
 Human PARP-2 Antibody |
|
32035-05111 |
AssayPro |
150 ug |
EUR 261 |
) PJ-34 (PARP inhibitor) |
|
SIH-366-10MG |
Stressmarq |
10 mg |
EUR 255 |
|
|
|
Description: The substance PJ-34 is a parp inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to yellow solid. which is May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml) . |
PJ-34 (PARP inhibitor) |
|
SIH-366-50MG |
Stressmarq |
50 mg |
EUR 786 |
|
|
|
Description: The substance PJ-34 is a parp inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to yellow solid. which is May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml) . |
) Rucaparib phosphate (PARP Inhibitor) |
|
SIH-580-25MG |
Stressmarq |
25 mg |
EUR 395 |
|
|
|
Description: The substance Rucaparib phosphate is a parp inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is yellow powder which is May be dissolved in DMSO (25 mg/ml). |
Rucaparib phosphate (PARP Inhibitor) |
|
SIH-580-5MG |
Stressmarq |
5 mg |
EUR 160 |
|
|
|
Description: The substance Rucaparib phosphate is a parp inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is yellow powder which is May be dissolved in DMSO (25 mg/ml). |
 Cleaved-PARP Conjugated Antibody |
|
C29033 |
SAB |
100ul |
EUR 397 |
 Protein) Mouse Poly ADP Ribose Polymerase (PARP) Protein |
|
20-abx068631 |
Abbexa |
-
EUR 732.00
-
EUR 286.00
-
EUR 2305.00
-
EUR 885.00
-
EUR 523.00
|
-
100 ug
-
10 ug
-
1 mg
-
200 ug
-
50 ug
|
|
|
Mouse Poly ADP Ribose Polymerase (PARP) Protein |
|
20-abx167515 |
Abbexa |
-
EUR 759.00
-
EUR 300.00
-
EUR 2388.00
-
EUR 913.00
-
EUR 537.00
|
-
100 ug
-
10 ug
-
1 mg
-
200 ug
-
50 ug
|
|
|
 ELISA Kit) Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit |
|
abx576739-96tests |
Abbexa |
96 tests |
EUR 864 |
|
|
 Cleaved PARP recombinant monoclonal antibody |
|
A5034 |
Bimake |
100ul X 3 |
EUR 595 |
|
|
|
Description: A recombinant monoclonal antibody from rabbit against human Cleaved PARP for WB,ELISA |
 [KO Validated] PARP Rabbit mAb |
|
A19596-100ul |
Abclonal |
100 ul |
EUR 410 |
[KO Validated] PARP Rabbit mAb |
|
A19596-200ul |
Abclonal |
200 ul |
EUR 571 |
[KO Validated] PARP Rabbit mAb |
|
A19596-20ul |
Abclonal |
20 ul |
EUR 221 |
[KO Validated] PARP Rabbit mAb |
|
A19596-50ul |
Abclonal |
50 ul |
EUR 287 |
 Monoclonal PARP Antibody, Clone: 7A10 |
|
APR08929G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A Monoclonal antibody against Human PARP. The antibodies are raised in Mouse and are from clone 7A10. This antibody is applicable in WB, FC, E |
) Monoclonal PARP Antibody (Clone 839120) |
|
APR08932G |
Leading Biology |
0.1ml |
EUR 528 |
|
Description: A Monoclonal antibody against Human PARP (Clone 839120). The antibodies are raised in Mouse. This antibody is applicable in WB and IHC |
 Antibody) Polyclonal Cleaved PARP (Asp214) Antibody |
|
APG02631G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cleaved PARP (Asp214) . This antibody is tested and proven to work in the following applications: |
All tumor tissue somatic DNA restore mutations had been detectable in cfDNA; allele frequency of somatic mutations decreased selectively in responding sufferers At illness development, following response to olaparib, a number of subclonal aberrations reverting germline and somatic DNA restore mutations (BRCA2, PALB2) again in body emerged as mechanisms of resistance. These knowledge assist the position of liquid biopsies as a predictive, prognostic, response, and resistance biomarker in metastatic prostate most cancers.Significance: We report prospectively deliberate, serial, cfDNA analyses from sufferers with metastatic prostate most cancers handled on an investigator-initiated part II trial of olaparib.
ELISA Kit)