Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.


Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.
PARP inhibitors are being developed as therapeutic brokers for most cancers. Greater than six compounds have entered scientific trials. The vast majority of these compounds are β-nicotinamide adenine dinucleotide (NAD(+))-competitive inhibitors. One exception is iniparib, which has been proposed to be a noncompetitive PARP inhibitor. On this research, we evaluate the biologic actions of two completely different structural lessons of NAD(+)-competitive compounds with iniparib and its C-nitroso metabolite. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells, and the first mechanism of motion for iniparib is probably going not by way of inhibition of PARP exercise.
Two chemical sequence of NAD(+)-competitive PARP inhibitors, iniparib and its C-nitroso metabolite, had been analyzed in enzymatic and mobile assays. Viability assays had been carried out in MDA-MB-436 (BRCA1-deficient) and DLD1(-/-) (BRCA2-deficient) cells along with BRCA-proficient MDA-MB-231 and DLD1(+/+) cells. Capan-1 and B16F10 xenograft fashions had been used to check iniparib and veliparib in vivo. Mass spectrometry and the (3)H-labeling methodology had been used to watch the covalent modification of proteins.
All NAD(+)-competitive inhibitors present sturdy exercise in a PARP mobile assay, strongly potentiate the exercise of temozolomide, and elicit sturdy cell killing in BRCA-deficient tumor cells in vitro and in vivo. Cell killing was related to an induction of DNA injury. In distinction, neither iniparib nor its C-nitroso metabolite inhibited PARP enzymatic or mobile exercise, potentiated temozolomide, or confirmed exercise in a BRCA-deficient setting. We discover that the nitroso metabolite of iniparib types adducts with many cysteine-containing proteins. Moreover, each iniparib and its nitroso metabolite type protein adducts nonspecifically in tumor cells.

To ensure that PARP inhibitors to enhance outcomes for sufferers, their sensitizing results have to be tumour particular. Early scientific knowledge point out that systemic toxicity could also be exacerbated, so future trials should deal with this challenge. The mechanism of motion of PARP inhibitors together with cytotoxic brokers can also be unsure. Amongst BRCA-deficient cancers, mechanisms of inherent and purchased resistance to PARP inhibitors are below investigation. Combining these brokers with radiotherapy seems promising however designing scientific trials to check the efficacy and toxicity of this mixture is problematic.

PARP inhibitors for BRCA1/2-mutated and sporadic ovarian most cancers: present follow and future instructions.

Poly(ADP-ribose) polymerase (PARP) inhibitors trigger focused tumour cell loss of life in homologous recombination (HR)-deficient cancers, together with BRCA-mutated tumours, by exploiting artificial lethality. PARP inhibitors are being evaluated in late-stage scientific trials of ovarian most cancers (OC). Just lately, olaparib was the primary PARP inhibitor accepted within the European Union and United States for the therapy of superior BRCA-mutated OC. This paper opinions the position of BRCA mutations for tumorigenesis and PARP inhibitor sensitivity, and summarises the scientific growth of PARP inhibitors for the therapy of sufferers identified with OC.

Among the many 5 key PARP inhibitors at the moment in scientific growth, olaparib has undergone probably the most intensive scientific investigation. PARP inhibitors have demonstrated sturdy antitumour exercise in BRCA-mutated superior OC as a single agent within the therapy and upkeep setting, significantly in platinum-sensitive illness. PARP inhibitors are nicely tolerated; nevertheless, additional cautious evaluation of average and late-onset toxicity is obligatory within the upkeep and adjuvant setting, respectively. PARP inhibitors are additionally being evaluated together with chemotherapeutic and novel focused brokers to potentiate antitumour actions.

Present analysis is extending using PARP inhibitors past BRCA mutations to different sensitising molecular defects that end in HR-deficient most cancers, and is defining an HR-deficiency signature. Trials are underway to find out whether or not such a signature will predict sensitivity to PARP inhibitors in girls with sporadic OC. In vitro talazoparib potentiated the toxicity of temozolomide as much as 85-fold, with marked potentiation in Ewing sarcoma and leukemia strains (30-50-fold). There was much less potentiation for topotecan. In vivo, talazoparib potentiated the toxicity of temozolomide, and mixture A and mixture B characterize the MTDs when mixed with low-dose or high-dose talazoparib, respectively.

Each mixtures demonstrated vital synergism in opposition to 5 of 10 Ewing sarcoma xenografts. The mix demonstrated modest exercise in opposition to most different xenograft fashions. Pharmacodynamic research confirmed a treatment-induced full lack of PARP solely in tumor fashions delicate to both talazoparib alone or talazoparib plus temozolomide. These analyses present predictive, prognostic, response, and resistance knowledge with “second hit” mutations first detectable at illness development, suggesting clonal evolution from treatment-selective strain and platinum resistance.

Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.

Circulating Cell-Free DNA to Information Prostate Most cancers Therapy with PARP Inhibition.

Biomarkers for extra exact affected person care are wanted in metastatic prostate most cancers. We’ve reported a part II trial (TOPARP-A) of the PARP inhibitor olaparib in metastatic prostate most cancers, demonstrating antitumor exercise associating with homologous recombination DNA restore defects. We now report focused and whole-exome sequencing of serial circulating cell-free DNA (cfDNA) samples collected throughout this trial. Decreases in cfDNA focus independently related to consequence in multivariable analyses.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit

RD-PARP-Mu-48Tests 48 Tests
EUR 533

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit

RD-PARP-Mu-96Tests 96 Tests
EUR 740

anti-PARP (M3)

LF-MA20421 100 ug
EUR 354
Description: Mouse monoclonal to PARP

anti-PARP (7A10)

LF-MA30362 100 ul
EUR 486
Description: Mouse Monoclonal to PARP

Anti-PARP antibody

STJ97033 200 µl
EUR 197
Description: Mouse monoclonal to PARP.

Anti-PARP (3G4)

YF-MA10018 100 ug
EUR 363
Description: Mouse monoclonal to PARP

Anti-PARP (2C7)

YF-MA11839 50 ug
EUR 363
Description: Mouse monoclonal to PARP

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

DLR-PARP-Hu-48T 48T
EUR 479
  • Should the Human Poly ADP Ribose Polymerase (PARP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase (PARP) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

DLR-PARP-Hu-96T 96T
EUR 621
  • Should the Human Poly ADP Ribose Polymerase (PARP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase (PARP) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

RDR-PARP-Hu-48Tests 48 Tests
EUR 500

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

RDR-PARP-Hu-96Tests 96 Tests
EUR 692

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

RD-PARP-Hu-48Tests 48 Tests
EUR 478

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

RD-PARP-Hu-96Tests 96 Tests
EUR 662

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-PARP-2 Antibody

A03270-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PARP-2 Antibody (PARP2) detection. Tested with WB in Human, Mouse.

Anti-PARP-3 Antibody

A03762 100ul
EUR 522
Description: Rabbit Polyclonal PARP-3 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse.

Anti-PARP-1 Antibody

A00122-1 100ul
EUR 397
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse.

Anti-PARP/PARP1 Antibody

PA2227 100ug/vial
EUR 294

anti-Cleaved PARP (M4)

LF-MA20422 100 ug
EUR 354
Description: Mouse monoclonal to Cleaved PARP

Anti-PARP/PARP1 Antibody

PB9309 100ug/vial
EUR 334

Anti-PARP-2 antibody

STJ94959 200 µl
EUR 197
Description: Rabbit polyclonal to PARP-2.

Anti-PARP-3 antibody

STJ94960 200 µl
EUR 197
Description: Rabbit polyclonal to PARP-3.

Anti-PARP-4 antibody

STJ94961 200 µl
EUR 197
Description: Rabbit polyclonal to PARP-4.

Anti-Cleaved PARP antibody

STJ97034 200 µl
EUR 197
Description: Mouse monoclonal to Cleaved PARP.

Anti-Cleaved PARP antibody

STJ97047 200 µl
EUR 197
Description: Cleaved-PARP-1 is a protein encoded by the PARP1 gene which is approximately 113 kDa. Cleaved-PARP-1 is localised to the nucleus. It is involved in telomere C-strand synthesis, transcription-coupled nucleotide excision repair and survival caspase cascades. It is a chromatin-associated enzyme, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is DNA dependent and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation. It also pays a role in the regulation of the molecular events involved in the recovery of cell from DNA damage. Cleaved-PARP-1 is expressed in the nervous system, liver, intestine, lung and eye. Mutations in the PARP1 gene may result in diphtheria and hemorrhagic cystitis. The antibody STJ97047 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels Cleaved-PARP-1.

Anti-PARP-1 antibody

STJ97648 200 µl
EUR 197
Description: Rabbit polyclonal to PARP-1.

Anti-PARP Rabbit Monoclonal Antibody

M00122 100ug/vial
EUR 397
Description: Rabbit Monoclonal PARP Antibody. Validated in IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Anti-PARP Rabbit Monoclonal Antibody

M00122-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal PARP Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-PARP-1 antibody (KLH)

STJ98308 100 µl
EUR 234
Description: Mouse monoclonal to PARP-1 (KLH).

PARP/ Rat PARP ELISA Kit

ELA-E0947r 96 Tests
EUR 886

PARP Mouse Monoclonal Antibody

38067-100ul 100ul
EUR 252

PARP Mouse Monoclonal Antibody

38067-50ul 50ul
EUR 187

Mouse PARP ELISA Kit

EMP0031 96Tests
EUR 521

PARP Antibody

3002-100
EUR 316

PARP Antibody

3002-30T
EUR 146

PARP antibody

20R-1423 100 ug
EUR 673
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-11555 100 ug
EUR 404
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-11640 100 ug
EUR 611
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-11641 100 ug
EUR 581
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-30801 100 ug
EUR 327
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-30803 100 ug
EUR 327
Description: Rabbit polyclonal PARP antibody

PARP antibody

10R-2170 100 ul
EUR 403
Description: Mouse monoclonal PARP antibody

PARP antibody

10R-8001 100 ul
EUR 503
Description: Mouse monoclonal PARP antibody

PARP antibody

10R-8057 100 ug
EUR 470
Description: Mouse polyclonal PARP antibody

PARP Antibody

48838-100ul 100ul
EUR 333

PARP Antibody

48838-50ul 50ul
EUR 239

PARP antibody

BF0719 200ul
EUR 376
Description: PARP mouse monoclonal antibody detects endogenous levels of total PPAR.

Anti-Cleaved PARP Rabbit Monoclonal Antibody

M00122-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Cleaved PARP Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Cleaved PARP Rabbit Monoclonal Antibody

M00122-2 100ug/vial
EUR 397
Description: Rabbit Monoclonal Cleaved PARP Antibody. Validated in Flow Cytometry, IP, IF, ICC, WB and tested in Human.

Anti-Cleaved-PARP-1 (G215) antibody

STJ90072 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-PARP-1 (G215).

Anti-Cleaved-PARP-1 (D214) antibody

STJ90100 200 µl
EUR 197
Description: Cleaved-PARP-1 is a protein encoded by the PARP1 gene which is approximately 113 kDa. Cleaved-PARP-1 is localised to the nucleus. It is involved in telomere C-strand synthesis, transcription-coupled nucleotide excision repair and survival caspase cascades. It is a chromatin-associated enzyme, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is DNA dependent and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation. It also pays a role in the regulation of the molecular events involved in the recovery of cell from DNA damage. Cleaved-PARP-1 is expressed in the nervous system, liver, intestine, lung and eye. Mutations in the PARP1 gene may result in diphtheria and hemorrhagic cystitis. The antibody STJ90100 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment activated PARP-1 protein resulting from cleavage adjacent to D214.

Anti-PARP-1 (Acetyl K521) antibody

STJ98846 200 µl
EUR 197
Description: Rabbit polyclonal to E2F-1.

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Cleaved PARP Mouse Monoclonal Antibody

38068-100ul 100ul
EUR 252

Cleaved PARP Mouse Monoclonal Antibody

38068-50ul 50ul
EUR 187

Cleaved PARP Mouse Monoclonal Antibody

38076-100ul 100ul
EUR 252

Cleaved PARP Mouse Monoclonal Antibody

38076-50ul 50ul
EUR 187

Cleaved-PARP antibody

29033-100ul 100ul
EUR 252

PARP (Cleaved) Antibody

3140-100
EUR 468

PARP (Cleaved) Antibody

3141-100
EUR 446

Cleaved PARP Antibody

48805-100ul 100ul
EUR 333

Cleaved PARP Antibody

48805-50ul 50ul
EUR 239

Cleaved PARP Antibody

abx020094-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

Cleaved-PARP Antibody

AF7023 200ul
EUR 376
Description: PARP (Cleaved-Asp214) Antibody detects endogenous levels of fragment of activated PARP resulting from cleavage adjacent to Asp214.

Polyclonal PARP Antibody

APR08928G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PARP . This antibody is tested and proven to work in the following applications:

Cleaved-PARP Antibody

BF9106 200ul
EUR 376
Description: The Cleaved PARP Mouse mAb can recognize endogenous pro and active PARP proteins.

Cleaved- PARP antibody

ABF7023 100 ug
EUR 438

PARP Monoclonal Antibody

ABM40131-003ml 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PARP Monoclonal Antibody

ABM40131-01ml 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PARP Monoclonal Antibody

ABM40131-02ml 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PARP Monoclonal Antibody

EM1131-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

PARP Monoclonal Antibody

EM1131-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Rabbit Anti-PARP monoclonal antibody, clone TV14-79

CABT-L652 100 ul
EUR 777

PARP Antibody (Clone 7A10)

3023-100
EUR 403

PARP Antibody (Clone 10H)

3000-100
EUR 370

PARP Antibody (Clone 839120)

6659-100
EUR 403

PARP Antibody (Clone 2B6)

A1109-100
EUR 359

Human PARP-2 Antibody

32035-05111 150 ug
EUR 261

PARP-1, human recombinant

4992-50
EUR 425

PARP (Cleaved-Asp214) Antibody

20-abx015613
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

PARP (Cleaved-Gly215) Antibody

20-abx015614
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Human PARP ELISA Kit

EHP0031 96Tests
EUR 521

Bovine PARP ELISA Kit

EBP0031 96Tests
EUR 521

Anserine PARP ELISA Kit

EAP0031 96Tests
EUR 521

Chicken PARP ELISA Kit

ECKP0031 96Tests
EUR 521

Canine PARP ELISA Kit

ECP0031 96Tests
EUR 521

Goat PARP ELISA Kit

EGTP0031 96Tests
EUR 521

Cleaved-PARP Blocking Peptide

AF7023-BP 1mg
EUR 195

Cleaved-PARP Conjugated Antibody

C29033 100ul
EUR 397

Polyclonal PARP (Cleaved) Antibody

APR08927G 0.1mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PARP (Cleaved) . This antibody is tested and proven to work in the following applications:

PARP antibody Blocking Peptide

BF0719-BP 1mg
EUR 195

Cleaved-PARP Blocking Peptide

BF9106-BP 1mg
EUR 195

PARP-4 Polyclonal Antibody

ABP53836-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-4 from Human. This PARP-4 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200

PARP-4 Polyclonal Antibody

ABP53836-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-4 from Human. This PARP-4 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200

PARP-4 Polyclonal Antibody

ABP53836-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-4 from Human. This PARP-4 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200

PARP-2 Polyclonal Antibody

ABP53414-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-2 from Human, Mouse. This PARP-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200

PARP-2 Polyclonal Antibody

ABP53414-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-2 from Human, Mouse. This PARP-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200

PARP-2 Polyclonal Antibody

ABP53414-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-2 from Human, Mouse. This PARP-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200

PARP-3 Polyclonal Antibody

ABP53415-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-3 from Human. This PARP-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90

PARP-3 Polyclonal Antibody

ABP53415-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-3 from Human. This PARP-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90

PARP-3 Polyclonal Antibody

ABP53415-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-3 from Human. This PARP-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90

Cleaved PARP Monoclonal Antibody

ABM40132-003ml 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40132-01ml 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40132-02ml 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40145-003ml 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40145-01ml 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40145-02ml 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PARP recombinant monoclonal antibody

A5037 100ul X 3
EUR 595
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
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Description: A recombinant monoclonal antibody from rabbit against human PARP for WB,ELISA

PARP-1 Polyclonal Antibody

ABP57383-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-1
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-1 from Human, Mouse, Rat. This PARP-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1

PARP-1 Polyclonal Antibody

ABP57383-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-1
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-1 from Human, Mouse, Rat. This PARP-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1

PARP-1 Polyclonal Antibody

ABP57383-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-1
  • Applications tips:
Description: A polyclonal antibody for detection of PARP-1 from Human, Mouse, Rat. This PARP-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1

PARP-1 Polyclonal Antibody

ES8376-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PARP-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

PARP-1 Polyclonal Antibody

ES8376-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PARP-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cleaved PARP Monoclonal Antibody

EM1132-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Monoclonal Antibody

EM1132-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Monoclonal Antibody

EM1145-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Monoclonal Antibody

EM1145-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Porcine PARP ELISA Kit

EPP0031 96Tests
EUR 521

PARP-4 Polyclonal Antibody

ES4835-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PARP-4 from Human. This antibody is tested and validated for IHC, WB, ELISA

PARP-4 Polyclonal Antibody

ES4835-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PARP-4 from Human. This antibody is tested and validated for IHC, WB, ELISA

PARP-2 Polyclonal Antibody

ES4413-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PARP-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

PARP-2 Polyclonal Antibody

ES4413-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PARP-2 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

PARP-3 Polyclonal Antibody

ES4414-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against PARP-3 from Human. This antibody is tested and validated for IHC, WB, ELISA

PARP-3 Polyclonal Antibody

ES4414-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against PARP-3 from Human. This antibody is tested and validated for IHC, WB, ELISA

Sheep PARP ELISA Kit

ESP0031 96Tests
EUR 521

Rat PARP ELISA Kit

ERP0031 96Tests
EUR 521

Rabbit PARP ELISA Kit

ERTP0031 96Tests
EUR 521

Monkey PARP ELISA Kit

EMKP0031 96Tests
EUR 521

Rucaparib phosphate (PARP Inhibitor)

SIH-580-25MG 25 mg
EUR 395
  • Rucaparib is a PARP1, PARP2 and PARP3 inhibitor and inhibits PARP-mediated DNA repair (1). It is being developed for ovarian, prostate and bladder cancers (2, 3).
Description: The substance Rucaparib phosphate is a parp inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is yellow powder which is May be dissolved in DMSO (25 mg/ml).

Rucaparib phosphate (PARP Inhibitor)

SIH-580-5MG 5 mg
EUR 160
  • Rucaparib is a PARP1, PARP2 and PARP3 inhibitor and inhibits PARP-mediated DNA repair (1). It is being developed for ovarian, prostate and bladder cancers (2, 3).
Description: The substance Rucaparib phosphate is a parp inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is yellow powder which is May be dissolved in DMSO (25 mg/ml).

PJ-34 (PARP inhibitor)

SIH-366-10MG 10 mg
EUR 255
  • PJ-34 is a selective inhibitor of Poly (ADP-Ribose) polymerase (PARP). Studies have shown that the use of PJ-34 on severe inflammatory diseases, in particular experimental allergic encephalomyelitis (EAE) have contributed to a shift of the immune res
  • Show more
Description: The substance PJ-34 is a parp inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to yellow solid. which is May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml) .

PJ-34 (PARP inhibitor)

SIH-366-50MG 50 mg
EUR 786
  • PJ-34 is a selective inhibitor of Poly (ADP-Ribose) polymerase (PARP). Studies have shown that the use of PJ-34 on severe inflammatory diseases, in particular experimental allergic encephalomyelitis (EAE) have contributed to a shift of the immune res
  • Show more
Description: The substance PJ-34 is a parp inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to yellow solid. which is May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml) .

Monoclonal antibody for PARP

SMC-259D 0.1ml
EUR 314
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is not conjugated.

Monoclonal antibody for PARP

SMC-259D-A390 0.1ml
EUR 361
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 390.

Monoclonal antibody for PARP

SMC-259D-A488 0.1ml
EUR 360
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 488.

Monoclonal antibody for PARP

SMC-259D-A565 0.1ml
EUR 360
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 565.

Monoclonal antibody for PARP

SMC-259D-A594 0.1ml
EUR 360
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 594.

Monoclonal antibody for PARP

SMC-259D-A633 0.1ml
EUR 360
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 633.

Monoclonal antibody for PARP

SMC-259D-A655 0.1ml
EUR 360
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 655.

Monoclonal antibody for PARP

SMC-259D-A680 0.1ml
EUR 360
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 680.

Monoclonal antibody for PARP

SMC-259D-A700 0.1ml
EUR 360
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 700.

Monoclonal antibody for PARP

SMC-259D-ALP 0.1ml
EUR 355
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Alkaline Phosphatase.

Monoclonal antibody for PARP

SMC-259D-APC 0.1ml
EUR 359
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with APC.

Monoclonal antibody for PARP

SMC-259D-APCCY7 0.1ml
EUR 432
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with APC/Cy7.

Monoclonal antibody for PARP

SMC-259D-BI 0.1ml
EUR 357
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Biotin.

Monoclonal antibody for PARP

SMC-259D-DY350 0.1ml
EUR 436
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 350.

Monoclonal antibody for PARP

SMC-259D-DY405 0.1ml
EUR 412
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 405.

Monoclonal antibody for PARP

SMC-259D-DY488 0.1ml
EUR 393
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 488.

Monoclonal antibody for PARP

SMC-259D-DY594 0.1ml
EUR 397
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 594.

Monoclonal antibody for PARP

SMC-259D-DY633 0.1ml
EUR 387
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Dylight 633.

Monoclonal antibody for PARP

SMC-259D-FITC 0.1ml
EUR 353
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with FITC.

Monoclonal antibody for PARP

SMC-259D-HRP 0.1ml
EUR 349
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with HRP.

Monoclonal antibody for PARP

SMC-259D-P594 0.1ml
EUR 367
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with PE/ATTO 594.

Monoclonal antibody for PARP

SMC-259D-PCP 0.1ml
EUR 359
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with PerCP.

Monoclonal antibody for PARP

SMC-259D-RPE 0.1ml
EUR 358
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with RPE.

Monoclonal antibody for PARP

SMC-259D-STR 0.1ml
EUR 359
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl
  • Show more
Description: A monoclonal antibody from clone M3 against Human | Mouse | Rat PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with Streptavidin.

Mouse Poly ADP Ribose Polymerase (PARP) Protein

20-abx167515
  • EUR 759.00
  • EUR 300.00
  • EUR 2388.00
  • EUR 913.00
  • EUR 537.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Mouse Poly ADP Ribose Polymerase (PARP) Protein

20-abx068631
  • EUR 732.00
  • EUR 286.00
  • EUR 2305.00
  • EUR 885.00
  • EUR 523.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Polyclonal Cleaved PARP (Asp214) Antibody

APG02631G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cleaved PARP (Asp214) . This antibody is tested and proven to work in the following applications:

Monoclonal PARP Antibody, Clone: 7A10

APR08929G 0.1ml
EUR 484
Description: A Monoclonal antibody against Human PARP. The antibodies are raised in Mouse and are from clone 7A10. This antibody is applicable in WB, FC, E

Monoclonal PARP Antibody (Clone 839120)

APR08932G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human PARP (Clone 839120). The antibodies are raised in Mouse. This antibody is applicable in WB and IHC

Cleaved PARP recombinant monoclonal antibody

A5034 100ul X 3
EUR 595
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
  • Show more
Description: A recombinant monoclonal antibody from rabbit against human Cleaved PARP for WB,ELISA

[KO Validated] PARP Rabbit mAb

A19596-100ul 100 ul
EUR 410

[KO Validated] PARP Rabbit mAb

A19596-200ul 200 ul
EUR 571

All tumor tissue somatic DNA restore mutations had been detectable in cfDNA; allele frequency of somatic mutations decreased selectively in responding sufferers At illness development, following response to olaparib, a number of subclonal aberrations reverting germline and somatic DNA restore mutations (BRCA2, PALB2) again in body emerged as mechanisms of resistance. These knowledge assist the position of liquid biopsies as a predictive, prognostic, response, and resistance biomarker in metastatic prostate most cancers.Significance: We report prospectively deliberate, serial, cfDNA analyses from sufferers with metastatic prostate most cancers handled on an investigator-initiated part II trial of olaparib.

November 2021
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