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PARP inhibitors are being developed as therapeutic brokers for most cancers. Greater than six compounds have entered scientific trials. The vast majority of these compounds are β-nicotinamide adenine dinucleotide (NAD(+))-competitive inhibitors. One exception is iniparib, which has been proposed to be a noncompetitive PARP inhibitor. On this research, we evaluate the biologic actions of two completely different structural lessons of NAD(+)-competitive compounds with iniparib and its C-nitroso metabolite. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells, and the first mechanism of motion for iniparib is probably going not by way of inhibition of PARP exercise.
Two chemical sequence of NAD(+)-competitive PARP inhibitors, iniparib and its C-nitroso metabolite, had been analyzed in enzymatic and mobile assays. Viability assays had been carried out in MDA-MB-436 (BRCA1-deficient) and DLD1(-/-) (BRCA2-deficient) cells along with BRCA-proficient MDA-MB-231 and DLD1(+/+) cells. Capan-1 and B16F10 xenograft fashions had been used to check iniparib and veliparib in vivo. Mass spectrometry and the (3)H-labeling methodology had been used to watch the covalent modification of proteins.
All NAD(+)-competitive inhibitors present sturdy exercise in a PARP mobile assay, strongly potentiate the exercise of temozolomide, and elicit sturdy cell killing in BRCA-deficient tumor cells in vitro and in vivo. Cell killing was related to an induction of DNA injury. In distinction, neither iniparib nor its C-nitroso metabolite inhibited PARP enzymatic or mobile exercise, potentiated temozolomide, or confirmed exercise in a BRCA-deficient setting. We discover that the nitroso metabolite of iniparib types adducts with many cysteine-containing proteins. Moreover, each iniparib and its nitroso metabolite type protein adducts nonspecifically in tumor cells.

To ensure that PARP inhibitors to enhance outcomes for sufferers, their sensitizing results have to be tumour particular. Early scientific knowledge point out that systemic toxicity could also be exacerbated, so future trials should deal with this challenge. The mechanism of motion of PARP inhibitors together with cytotoxic brokers can also be unsure. Amongst BRCA-deficient cancers, mechanisms of inherent and purchased resistance to PARP inhibitors are below investigation. Combining these brokers with radiotherapy seems promising however designing scientific trials to check the efficacy and toxicity of this mixture is problematic.

PARP inhibitors for BRCA1/2-mutated and sporadic ovarian most cancers: present follow and future instructions.

Poly(ADP-ribose) polymerase (PARP) inhibitors trigger focused tumour cell loss of life in homologous recombination (HR)-deficient cancers, together with BRCA-mutated tumours, by exploiting artificial lethality. PARP inhibitors are being evaluated in late-stage scientific trials of ovarian most cancers (OC). Just lately, olaparib was the primary PARP inhibitor accepted within the European Union and United States for the therapy of superior BRCA-mutated OC. This paper opinions the position of BRCA mutations for tumorigenesis and PARP inhibitor sensitivity, and summarises the scientific growth of PARP inhibitors for the therapy of sufferers identified with OC.

Among the many 5 key PARP inhibitors at the moment in scientific growth, olaparib has undergone probably the most intensive scientific investigation. PARP inhibitors have demonstrated sturdy antitumour exercise in BRCA-mutated superior OC as a single agent within the therapy and upkeep setting, significantly in platinum-sensitive illness. PARP inhibitors are nicely tolerated; nevertheless, additional cautious evaluation of average and late-onset toxicity is obligatory within the upkeep and adjuvant setting, respectively. PARP inhibitors are additionally being evaluated together with chemotherapeutic and novel focused brokers to potentiate antitumour actions.

Present analysis is extending using PARP inhibitors past BRCA mutations to different sensitising molecular defects that end in HR-deficient most cancers, and is defining an HR-deficiency signature. Trials are underway to find out whether or not such a signature will predict sensitivity to PARP inhibitors in girls with sporadic OC. In vitro talazoparib potentiated the toxicity of temozolomide as much as 85-fold, with marked potentiation in Ewing sarcoma and leukemia strains (30-50-fold). There was much less potentiation for topotecan. In vivo, talazoparib potentiated the toxicity of temozolomide, and mixture A and mixture B characterize the MTDs when mixed with low-dose or high-dose talazoparib, respectively.

Each mixtures demonstrated vital synergism in opposition to 5 of 10 Ewing sarcoma xenografts. The mix demonstrated modest exercise in opposition to most different xenograft fashions. Pharmacodynamic research confirmed a treatment-induced full lack of PARP solely in tumor fashions delicate to both talazoparib alone or talazoparib plus temozolomide. These analyses present predictive, prognostic, response, and resistance knowledge with “second hit” mutations first detectable at illness development, suggesting clonal evolution from treatment-selective strain and platinum resistance.

Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.

Circulating Cell-Free DNA to Information Prostate Most cancers Therapy with PARP Inhibition.

Biomarkers for extra exact affected person care are wanted in metastatic prostate most cancers. We’ve reported a part II trial (TOPARP-A) of the PARP inhibitor olaparib in metastatic prostate most cancers, demonstrating antitumor exercise associating with homologous recombination DNA restore defects. We now report focused and whole-exome sequencing of serial circulating cell-free DNA (cfDNA) samples collected throughout this trial. Decreases in cfDNA focus independently related to consequence in multivariable analyses.

PARP Mouse Monoclonal Antibody
E038067 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PARP Mouse Monoclonal Antibody
E12-159 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PARP Mouse Monoclonal Antibody
EM1131-100ul 100ul
EUR 124
Description: A Mouse Monoclonal antibody against PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

PARP Mouse Monoclonal Antibody
EM1131-50ul 50ul
EUR 74
Description: A Mouse Monoclonal antibody against PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

PARP-2, mouse recombinant
BC-033 20 ug
EUR 863

Mouse PARP ELISA Kit
EMP0031 96Tests
EUR 625.2

Anti- PARP-2 Antibody
GWB-8A4FF8 0.1 ml Ask for price

PARP Mouse Monoclonal Antibody(M3)
RA10397-100ul 100 ul
EUR 298

PARP Mouse Monoclonal Antibody(M3)
RA10397-50ul 50 ul
EUR 198

Mouse Monoclonal Antibody to PARP
sAP-0369 50ug
EUR 270

Rat Monoclonal anti-mouse PARP-1
mAP-0301 100ug
EUR 250

Anti-PARP/PARP1 Antibody
PB9309 100ug/vial
EUR 400.8

Anti-PARP/PARP1 Antibody
PA2227 100ug/vial
EUR 352.8

Cleaved PARP Mouse Monoclonal Antibody
38068 100ul
EUR 319

Cleaved PARP Mouse Monoclonal Antibody
38068-100ul 100ul
EUR 302.4

Cleaved PARP Mouse Monoclonal Antibody
38068-50ul 50ul
EUR 224.4

Cleaved PARP Mouse Monoclonal Antibody
38076 100ul
EUR 319

Cleaved PARP Mouse Monoclonal Antibody
38076-100ul 100ul
EUR 302.4

Cleaved PARP Mouse Monoclonal Antibody
38076-50ul 50ul
EUR 224.4

Cleaved PARP Mouse Monoclonal Antibody
E038068 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Cleaved PARP Mouse Monoclonal Antibody
E038076 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Cleaved PARP Mouse Monoclonal Antibody
E12-160 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Cleaved PARP Mouse Monoclonal Antibody
E12-173 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Cleaved PARP Mouse Monoclonal Antibody
EM1132-100ul 100ul
EUR 124
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Mouse Monoclonal Antibody
EM1132-50ul 50ul
EUR 74
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Mouse Monoclonal Antibody
EM1145-100ul 100ul
EUR 124
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Mouse Monoclonal Antibody
EM1145-50ul 50ul
EUR 74
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Mouse Monoclonal PARP Antibody (194C1439)
TA336426 100 µg Ask for price

anti-Cleaved PARP (M4)
LF-MA20422 100 ug
EUR 424.8
Description: Mouse monoclonal to Cleaved PARP

Anti-PARP Mouse mAb
E2250069 100ul
EUR 225
Description: Available in various conjugation types.

Anti-Cleaved PARP antibody
STJ97034 200 µl
EUR 236.4
Description: Mouse monoclonal to Cleaved PARP.

Anti-Cleaved PARP antibody
STJ97047 200 µl
EUR 236.4
Description: Cleaved-PARP-1 is a protein encoded by the PARP1 gene which is approximately 113 kDa. Cleaved-PARP-1 is localised to the nucleus. It is involved in telomere C-strand synthesis, transcription-coupled nucleotide excision repair and survival caspase cascades. It is a chromatin-associated enzyme, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is DNA dependent and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation. It also pays a role in the regulation of the molecular events involved in the recovery of cell from DNA damage. Cleaved-PARP-1 is expressed in the nervous system, liver, intestine, lung and eye. Mutations in the PARP1 gene may result in diphtheria and hemorrhagic cystitis. The antibody STJ97047 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels Cleaved-PARP-1.

Cleaved PARP Mouse Monoclonal Antibody(M4)
RA10398-100ul 100 ul
EUR 298

Cleaved PARP Mouse Monoclonal Antibody(M4)
RA10398-50ul 50 ul
EUR 198

Genorise® recombinant mouse PARP protein
GR124198 5 µg
EUR 285

Anti-Cleaved PARP Antibody [SU0314]
ET1608-10 100ul
EUR 231
Description: Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. Once PARP detects a SSB, it binds to the DNA, undergoes a structural change, and begins the synthesis of a polymeric adenosine diphosphate ribose (poly (ADP-ribose) or PAR) chain, which acts as a signal for the other DNA-repairing enzymes. Target enzymes include DNA ligase III (LigIII), DNA polymerase beta (polβ), and scaffolding proteins such as X-ray cross-complementing gene 1 (XRCC1). After repairing, the PAR chains are degraded via Poly(ADP-ribose) glycohydrolase (PARG). PARP enzymes are essential in a number of cellular functions, including expression of inflammatory genes: PARP1 is required for the induction of ICAM-1 gene expression by cardiac myocytes and smooth muscle cells, in response to TNF.

Anti-Cleaved PARP Antibody [SU0314]
ET1608-10TR 20ul
EUR 64.35
Description: Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. Once PARP detects a SSB, it binds to the DNA, undergoes a structural change, and begins the synthesis of a polymeric adenosine diphosphate ribose (poly (ADP-ribose) or PAR) chain, which acts as a signal for the other DNA-repairing enzymes. Target enzymes include DNA ligase III (LigIII), DNA polymerase beta (polβ), and scaffolding proteins such as X-ray cross-complementing gene 1 (XRCC1). After repairing, the PAR chains are degraded via Poly(ADP-ribose) glycohydrolase (PARG). PARP enzymes are essential in a number of cellular functions, including expression of inflammatory genes: PARP1 is required for the induction of ICAM-1 gene expression by cardiac myocytes and smooth muscle cells, in response to TNF.

PARP/ Rat PARP ELISA Kit
ELA-E0947r 96 Tests
EUR 1063.2

Mouse Monoclonal anti-PARP Antibody
TA327935 100 µg Ask for price

PARP antibody
10R-2170 100 ul
EUR 468
Description: Mouse monoclonal PARP antibody

PARP antibody
10R-8001 100 ul
EUR 455
Description: Mouse monoclonal PARP antibody

PARP antibody
10R-8057 100 ug
EUR 413
Description: Mouse polyclonal PARP antibody

PARP antibody
20R-1423 100 ug
EUR 807.6
Description: Rabbit polyclonal PARP antibody

PARP Antibody
3002-100 each
EUR 379.2

PARP Antibody
3002-30T each
EUR 175.2

PARP Antibody
48838 100ul
EUR 499

PARP Antibody
48838-100ul 100ul
EUR 399.6

PARP Antibody
48838-50ul 50ul
EUR 286.8

PARP Antibody
E10-30016 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PARP Antibody
F47592-0.08ML 0.08 ml
EUR 140.25
Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. [UniProt]

PARP Antibody
F47598-0.08ML 0.08 ml
EUR 140.25
Description: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. [UniProt]

PARP Antibody
F49614-0.08ML 0.08 ml
EUR 140.25
Description: PARP is a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

PARP Antibody
F49614-0.4ML 0.4 ml
EUR 322.15
Description: PARP is a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

PARP Antibody
E90101 100ug
EUR 255
Description: Available in various conjugation types.

PARP Antibody
E300944 100ug/200ul
EUR 275
Description: Available in various conjugation types.

PARP antibody
70R-30801 100 ug
EUR 294
Description: Rabbit polyclonal PARP antibody

PARP antibody
70R-30803 100 ug
EUR 294
Description: Rabbit polyclonal PARP antibody

PARP antibody
70R-11555 100 ug
EUR 343
Description: Rabbit polyclonal PARP antibody

PARP antibody
70R-11640 100 ug
EUR 539
Description: Rabbit polyclonal PARP antibody

PARP antibody
70R-11641 100 ug
EUR 511
Description: Rabbit polyclonal PARP antibody

PARP antibody
BF0719 200ul
EUR 540

PARP antibody
BF0719-100ul 100ul
EUR 350

PARP antibody
BF0719-200ul 200ul
EUR 450

PARP antibody
BF0719-50ul 50ul
EUR 250

PARP, Antibody
GWB-94B150 7 ml Ask for price

PARP, Antibody
GWB-FDFF8F 1 ml Ask for price

PARP Antibody
R31722 100 ug
EUR 356.15
Description: Poly [ADP-ribose] polymerase 1 is composed of four domains: a DNA-binding domain, a caspase-cleaved domain, an auto-modification domain, and a catalytic domain. In vivo, PARP is cleaved by caspases -3 and -7 between aspartic acid 214 and glycine 215, resulting in a 24KD subunit (containing the DNA binding zinc finger motif) and a 89KD subunit (containing the catalytic and auto-modification domains). PARP is an enzyme that modifies nuclear proteins. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage.

PARP
E8ET1608-56 100ul
EUR 275
Description: Available in various conjugation types.

Cleaved PARP Mouse Monoclonal Antibody(Mix-mA™)
RA10406-100ul 100 ul
EUR 298

Cleaved PARP Mouse Monoclonal Antibody(Mix-mA™)
RA10406-50ul 50 ul
EUR 198

Recombinant Mouse PARP-1 Protein (His Tag)(Active)
PKSM040501-100ug 100ug
EUR 855
Description: Mouse

Anti-PARP produced in mouse Antibody
Y061494 100 µl
EUR 385

Mouse Poly ADP Ribose Polymerase (PARP) Protein
20-abx068631
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Poly ADP Ribose Polymerase (PARP) Protein
20-abx167515
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Anti-Cleaved PARP Rabbit Monoclonal Antibody
M00122-1 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal Cleaved PARP Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Cleaved PARP Rabbit Monoclonal Antibody
M00122-2 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal Cleaved PARP Antibody. Validated in Flow Cytometry, IP, IF, ICC, WB and tested in Human.

Mouse PARP(Poly ADP Ribose Polymerase) ELISA Kit
ELK9818-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PARP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PARP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PARP, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PARP in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse PARP(Poly ADP Ribose Polymerase) ELISA Kit
ELK9818-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PARP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PARP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse PARP, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PARP in the samples is then determined by comparing the OD of the samples to the standard curve.

PARP 1 Antibody
F47598-0.4ML 0.4 ml
EUR 322.15
Description: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. [UniProt]

PARP (Cleaved) Antibody
3140-100 each
EUR 561.6

PARP (Cleaved) Antibody
3141-100 each
EUR 535.2

Cleaved PARP Antibody
48805 100ul
EUR 499

Cleaved PARP Antibody
48805-100ul 100ul
EUR 399.6

Cleaved PARP Antibody
48805-50ul 50ul
EUR 286.8

Cleaved PARP Antibody
abx020094-100ug 100 ug
EUR 526.8

Cleaved- PARP antibody
ABF7023 100 ug
EUR 525.6

PARP cleaved Antibody
GWB-ABA463 0.05 mg Ask for price

Poly ADP Ribose Polymerase (PARP) Polyclonal Antibody (Human, Mouse)
4-PAA279Mu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Poly ADP Ribose Polymerase (PARP)

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
DLR-PARP-Mu 96T
EUR 475
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
DLR-PARP-Mu-48T 48T
EUR 632.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Poly ADP Ribose Polymerase (PARP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
DLR-PARP-Mu-96T 96T
EUR 825.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Poly ADP Ribose Polymerase (PARP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
EKU11882-48T 48T
EUR 514.08

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
EKU11882-5x96T 5x96T
EUR 3488.4

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
EKU11882-96T 96T
EUR 734.4

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
EKN52993-48T 48T
EUR 320.04

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
EKN52993-5x96T 5x96T
EUR 2171.7

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
EKN52993-96T 96T
EUR 457.2

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
EKL54857-5x96T 5x96T
EUR 3702.63

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
EKL54857-96T 96T
EUR 779.5

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
DL-PARP-Mu 96T
EUR 453
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
EK15971 96Т
EUR 768

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
abx576739-96tests 96 tests
EUR 1036.8

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
RD-PARP-Mu-48T 48T
EUR 464.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
RD-PARP-Mu-48Tests 48 Tests
EUR 639.6

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
RD-PARP-Mu-96T 96T
EUR 663.3
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
RD-PARP-Mu-96Tests 96 Tests
EUR 888

Mouse Poly ADP ribose polymerase(PARP)ELISA Kit
QY-E21217 96T
EUR 433.2

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
RDR-PARP-Mu-48T 48T
EUR 487.52
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
RDR-PARP-Mu-48Tests 48 Tests
EUR 668.4

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
RDR-PARP-Mu-96T 96T
EUR 696.47
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit
RDR-PARP-Mu-96Tests 96 Tests
EUR 928.8

Cleaved PARP
E8ET1608-10 100ul
EUR 275
Description: Available in various conjugation types.

PARP Monoclonal Antibody
E20-53131 100ug
EUR 225
Description: Available in various conjugation types.

Polyclonal PARP Antibody
APR08928G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PARP . This antibody is tested and proven to work in the following applications:

PARP Monoclonal Antibody
ABM40131-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PARP Monoclonal Antibody
ABM40131-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PARP Monoclonal Antibody
ABM40131-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Mouse PARP-2 [ARTD2] high purity Recombinant Protein His Tag
IMSPARP2ARTD2HPRHIS10UG each
EUR 657
Description: Mouse PARP-2 [ARTD2] high purity Recombinant Protein His Tag

PARP-1 Polyclonal Antibody
E11-126210 100ul
EUR 225
Description: Available in various conjugation types.

PARP-2 Polyclonal Antibody
E20-73594 100ug
EUR 225
Description: Available in various conjugation types.

PARP-3 Polyclonal Antibody
E20-73595 100ug
EUR 225
Description: Available in various conjugation types.

PARP-4 Polyclonal Antibody
E20-73596 100ug
EUR 225
Description: Available in various conjugation types.

PARP-1 Polyclonal Antibody
E20-75695 100ug
EUR 225
Description: Available in various conjugation types.

PARP-4 Polyclonal Antibody
ABP53836-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PARP-4 from Human. This PARP-4 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200

PARP-4 Polyclonal Antibody
ABP53836-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PARP-4 from Human. This PARP-4 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200

PARP-4 Polyclonal Antibody
ABP53836-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PARP-4 from Human. This PARP-4 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-4 at AA rangle: 1120-1200

PARP-2 Polyclonal Antibody
ABP53414-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PARP-2 from Human, Mouse. This PARP-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200

PARP-2 Polyclonal Antibody
ABP53414-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PARP-2 from Human, Mouse. This PARP-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200

PARP-2 Polyclonal Antibody
ABP53414-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PARP-2 from Human, Mouse. This PARP-2 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-2 at AA rangle: 120-200

PARP-3 Polyclonal Antibody
ABP53415-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PARP-3 from Human. This PARP-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90

PARP-3 Polyclonal Antibody
ABP53415-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PARP-3 from Human. This PARP-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90

PARP-3 Polyclonal Antibody
ABP53415-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PARP-3 from Human. This PARP-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human PARP-3 at AA rangle: 10-90

PARP-1 Polyclonal Antibody
ABP57383-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PARP-1 from Human, Mouse, Rat. This PARP-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1

PARP-1 Polyclonal Antibody
ABP57383-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PARP-1 from Human, Mouse, Rat. This PARP-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1

PARP-1 Polyclonal Antibody
ABP57383-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PARP-1 from Human, Mouse, Rat. This PARP-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1

PARP-3 Polyclonal Antibody
E44H05802 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PARP-4 Polyclonal Antibody
E44H05803 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PARP-1 Polyclonal Antibody
E44H07137 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PARP-2 Polyclonal Antibody
E44H02978 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PARP-1 Polyclonal Antibody
E44H14763 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Mouse monoclonal anti-PARP antibody, clone 7A10
TA318859 100 µl Ask for price

Poly ADP Ribose Polymerase (PARP) Polyclonal Antibody (Human, Mouse), PE
4-PAA279Mu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Poly ADP Ribose Polymerase (PARP). This antibody is labeled with PE.

Poly ADP Ribose Polymerase (PARP) Polyclonal Antibody (Human, Mouse), APC
4-PAA279Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Poly ADP Ribose Polymerase (PARP). This antibody is labeled with APC.

Poly ADP Ribose Polymerase (PARP) Polyclonal Antibody (Human, Mouse), Cy3
4-PAA279Mu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Poly ADP Ribose Polymerase (PARP). This antibody is labeled with Cy3.

Poly ADP Ribose Polymerase (PARP) Polyclonal Antibody (Human, Mouse), HRP
4-PAA279Mu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Poly ADP Ribose Polymerase (PARP). This antibody is labeled with HRP.

Poly ADP Ribose Polymerase (PARP) Polyclonal Antibody (Human, Mouse), FITC
4-PAA279Mu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Poly ADP Ribose Polymerase (PARP). This antibody is labeled with FITC.

PARP Antibody (Clone 839120)
6659-100 each
EUR 483.6

PARP Antibody, Clone M3
SMC-259D 0.1ml
EUR 286
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is not conjugated.

PARP-1 (ab-2), Antibody
GWB-85D935 0.1 mg Ask for price

PARP Antibody (Clone 10H)
3000-100 each
EUR 444

PARP Antibody (Clone 2B6)
A1109-100 each
EUR 430.8

PARP Antibody (Clone 7A10)
3023-100 each
EUR 483.6

PARP cleaved Antibody (FITC)
GWB-1B93CA 0.5 ml Ask for price

PARP Antibody (phospho-S41)
F48729-0.08ML 0.08 ml
EUR 140.25
Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

PARP Monoclonal Antibody(M3)
E44H10781 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Poly ADP Ribose Polymerase (PARP) Polyclonal Antibody (Human, Mouse), Biotinylated
4-PAA279Mu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Poly ADP Ribose Polymerase (PARP). This antibody is labeled with Biotin.

PARP-1 Knockout Immortalized Mouse Heart Endothelial (HYKO6) Cell Line
T3031 1x10^6 cells / 1.0 ml
EUR 3950

PARP Antibody (phospho-S177)
F48726-0.08ML 0.08 ml
EUR 140.25
Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

PARP Antibody (phospho-S372)
F48728-0.08ML 0.08 ml
EUR 140.25
Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

PARP Antibody (phospho-S864)
F48731-0.08ML 0.08 ml
EUR 140.25
Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

PARP Antibody (phospho-T368)
F48732-0.08ML 0.08 ml
EUR 140.25
Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

PARP Antibody (phospho-S373)
F48734-0.08ML 0.08 ml
EUR 140.25
Description: Catalyzes poly (ADP-ribose) protein modification; plays a role in DNA repair and genome stability [RGD].

Monoclonal antibody for PARP
SMC-259D-A565 0.1ml
EUR 432
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 565.

Monoclonal antibody for PARP
SMC-259D-A633 0.1ml
EUR 432
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 633.

Monoclonal antibody for PARP
SMC-259D-A655 0.1ml
EUR 432
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 655.

Monoclonal antibody for PARP
SMC-259D-A680 0.1ml
EUR 432
Description: A monoclonal antibody from clone M3 against Human | Mouse PARP. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human PARP. The antibody is tested and validated for WB assays with the following recommended dilutions: WB (1:2000). This MAb for PARP is conjugated with ATTO 680.

All tumor tissue somatic DNA restore mutations had been detectable in cfDNA; allele frequency of somatic mutations decreased selectively in responding sufferers At illness development, following response to olaparib, a number of subclonal aberrations reverting germline and somatic DNA restore mutations (BRCA2, PALB2) again in body emerged as mechanisms of resistance. These knowledge assist the position of liquid biopsies as a predictive, prognostic, response, and resistance biomarker in metastatic prostate most cancers.Significance: We report prospectively deliberate, serial, cfDNA analyses from sufferers with metastatic prostate most cancers handled on an investigator-initiated part II trial of olaparib.

By Connie StoneTags: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,