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Impaired DNA harm response pathways might create vulnerabilities of most cancers cells that may be exploited therapeutically. One such selective vulnerability is the sensitivity of BRCA1- or BRCA2-defective tumors (therefore faulty in DNA restore by homologous recombination, HR) to inhibitors of the poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme important for restore pathways various to HR. Whereas promising, remedy with PARP-1 inhibitors (PARP-1i) faces some hurdles, together with (1) acquired resistance, (2) seek for different sensitizing, non-BRCA1/2 most cancers defects and (3) lack of biomarkers to foretell response to PARP-1i.

Right here we addressed these points utilizing PARP-1i on 20 human cell traces from carcinomas of the breast, prostate, colon, pancreas and ovary. Aberrations of the Mre11-Rad50-Nbs1 (MRN) advanced sensitized most cancers cells to PARP-1i, whereas p53 standing was much less predictive, even in response to PARP-1i combos with camptothecin or ionizing radiation. Moreover, monitoring PARsylation and Rad51 foci formation as surrogate markers for PARP exercise and HR, respectively, supported their candidacy for biomarkers of PARP-1i responses. As to resistance mechanisms, we confirmed the function of the multidrug resistance efflux transporters and its reversibility.

Extra importantly, we demonstrated that shRNA lentivirus-mediated depletion of 53BP1 in human BRCA1-mutant breast most cancers cells elevated their resistance to PARP-1i. Given the preferential lack of 53BP1 in BRCA-defective and triple-negative breast carcinomas, our findings warrant evaluation of 53BP1 amongst candidate predictive biomarkers of response to PARPi. Total, this research helps characterize genetic and purposeful determinants of mobile responses to PARP-1i and contributes to the seek for biomarkers to take advantage of PARP inhibitors in most cancers remedy.

Since many anti-cancer brokers act by inflicting DNA harm on tumour cells, there may be rising curiosity in the usage of inhibitors of DNA restore to extend the cytotoxicity of those brokers. Poly(ADP-ribose) polymerase (PARP) is an ample nuclear enzyme that binds to websites of DNA harm and promotes restore by modifying quite a lot of key proteins. Potent and particular inhibitors of PARP can be found; these have been proven to extend the cytotoxicity of a variety of anti-cancer brokers together with temozolomide, irinotecan and radiation. The PARP pathway and its inhibition thus provides quite a lot of alternatives for therapeutic intervention in each most cancers and different illness states.

Evaluate of poly (ADP-ribose) polymerase (PARP) mechanisms of motion and rationale for focusing on in most cancers and different illnesses.

Poly (ADP-ribose) polymerases (PARPs) are a household of associated enzymes that share the flexibility to catalyze the switch of ADP-ribose to focus on proteins. PARPs play an essential function in numerous mobile processes, together with modulation of chromatin construction, transcription, replication, recombination, and DNA restore. The function of PARP proteins in DNA restore is of explicit curiosity, in view of the discovering that sure tumors faulty in homologous recombination mechanisms, might depend on PARP-mediated DNA restore for survival, and are delicate to its inhibition. PARP inhibitors can also improve tumor sensitivity to DNA-damaging brokers.

Medical trials of PARP inhibitors are investigating the utility of those approaches in most cancers. The hyperactivation of PARP has additionally been proven to lead to a selected programmed cell demise pathway involving NAD+/ATP depletion, mu-calpain activation, lack of mitochondrial membrane potential, and the discharge of apoptosis inducing issue. Hyperactivation of the PARP pathway could also be exploited to selectively kill most cancers cells. Different PARP varieties, together with tankyrase 1 (PARP 5a), which performs an essential function in enhancing telomere elongation by telomerase, have been discovered to be potential targets in most cancers remedy.

Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.

PARP inhibitors: new companions within the remedy of most cancers and inflammatory illnesses.

Poly(ADP-ribose) polymerases (PARPs) are outlined as cell signaling enzymes that catalyze the switch of ADP-ribose items from NAD(+) to quite a lot of acceptor proteins. PARP-1, the very best characterised member of the PARP household, which presently contains 18 members, is an ample nuclear enzyme implicated in mobile responses to DNA harm provoked by genotoxic stress. PARP is concerned in DNA restore and transcriptional regulation and is now acknowledged as a key regulator of cell survival and cell demise in addition to a grasp part of quite a lot of transcription elements concerned in tumor growth and irritation.

PARP-1 is important to the restore of DNA single-strand breaks through the bottom excision restore pathway. Inhibitors of PARP-1 have been proven to reinforce the cytotoxic results of ionizing radiation and DNA-damaging chemotherapy brokers, such because the methylating brokers and topoisomerase I inhibitors. There are presently at the very least 5 PARP inhibitors in medical trial growth. Latest in vitro and in vivo proof means that PARP inhibitors may very well be used not solely as chemo/radiotherapy sensitizers, but additionally as single brokers to selectively kill cancers faulty in DNA restore,

particularly cancers with mutations within the breast cancer-associated genes (BRCA1 and BRCA2). PARP turns into activated in response to oxidative DNA harm and depletes mobile power swimming pools, thus resulting in mobile dysfunction in numerous tissues. The activation of PARP can also induce numerous cell demise processes and promotes an inflammatory response related to a number of organ failure. Inhibition of PARP exercise is protecting in a variety of inflammatory and ischemia-reperfusion-associated illnesses, together with cardiovascular illnesses, diabetes, rheumatoid arthritis, endotoxic shock, and stroke.

PARP (Cleaved) Antibody
3141-100 each
EUR 535.2

PARP cleaved Antibody
GWB-ABA463 0.05 mg Ask for price

Cleaved PARP Monoclonal Antibody
E20-53132 100ug
EUR 225
Description: Available in various conjugation types.

Cleaved PARP Monoclonal Antibody
E20-53145 100ug
EUR 225
Description: Available in various conjugation types.

Cleaved PARP Monoclonal Antibody
ABM0043-100uL 100 μL
EUR 229
Description: Mouse Anti-Cleaved PARP Monoclonal Antibody

Cleaved PARP Monoclonal Antibody
ABM40132-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody
ABM40132-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody
ABM40132-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody
ABM40145-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody
ABM40145-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody
ABM40145-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody
ABM0043-each each Ask for price

Cleaved PARP Monoclonal Antibody
ABM0043-Null Null Ask for price

PARP cleaved Antibody (FITC)
GWB-1B93CA 0.5 ml Ask for price

PARP (Cleaved-Asp214) Antibody
E11-0365L 100μg
EUR 225
Description: Available in various conjugation types.

PARP (Cleaved-Gly215) Antibody
E11-0366L 100μg
EUR 225
Description: Available in various conjugation types.

PARP (Cleaved-Asp214) Antibody
8L0365 50ug
EUR 368
Description: PARP (Cleaved-Asp214) Antibody

PARP (Cleaved-Gly215) Antibody
8L0366 50ug
EUR 368
Description: PARP (Cleaved-Gly215) Antibody

PARP (Cleaved-Asp214) Antibody
20-abx015613
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

PARP (Cleaved-Gly215) Antibody
20-abx015614
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  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Cleaved PARP Monoclonal Antibody(M4)
E44H10782 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Polyclonal PARP (Cleaved) Antibody
APR08927G 0.1mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PARP (Cleaved) . This antibody is tested and proven to work in the following applications:

Cleaved PARP Monoclonal Antibody(Mix)
E44H10795 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Cleaved PARP Mouse Monoclonal Antibody
38068 100ul
EUR 319

Cleaved PARP Mouse Monoclonal Antibody
38068-100ul 100ul
EUR 302.4

Cleaved PARP Mouse Monoclonal Antibody
38068-50ul 50ul
EUR 224.4

Cleaved PARP Mouse Monoclonal Antibody
38076 100ul
EUR 319

Cleaved PARP Mouse Monoclonal Antibody
38076-100ul 100ul
EUR 302.4

Cleaved PARP Mouse Monoclonal Antibody
38076-50ul 50ul
EUR 224.4

Cleaved PARP Mouse Monoclonal Antibody
E038068 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Cleaved PARP Mouse Monoclonal Antibody
E038076 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Cleaved PARP Mouse Monoclonal Antibody
E12-160 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Cleaved PARP Mouse Monoclonal Antibody
E12-173 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Cleaved PARP Mouse Monoclonal Antibody
EM1132-100ul 100ul
EUR 124
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Mouse Monoclonal Antibody
EM1132-50ul 50ul
EUR 74
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Mouse Monoclonal Antibody
EM1145-100ul 100ul
EUR 124
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Mouse Monoclonal Antibody
EM1145-50ul 50ul
EUR 74
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Polyclonal Cleaved PARP (Asp214) Antibody
APG02631G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cleaved PARP (Asp214) . This antibody is tested and proven to work in the following applications:

Cleaved PARP (Asp214) Polyclonal Antibody
E-AB-93361-120uL 120uL
EUR 320
Description: Unconjugated

Cleaved PARP (Asp214) Polyclonal Antibody
E-AB-93361-200uL 200uL
EUR 530
Description: Unconjugated

Cleaved PARP (Asp214) Polyclonal Antibody
E-AB-93361-60uL 60uL
EUR 200
Description: Unconjugated

Cleaved PARP (Asp214) Polyclonal Antibody
E-AB-93361-each each Ask for price
Description: Unconjugated

Cleaved PARP
E8ET1608-10 100ul
EUR 275
Description: Available in various conjugation types.

Cleaved PARP recombinant monoclonal antibody
A5034 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human Cleaved PARP for WB,ELISA

Cleaved PARP Mouse Monoclonal Antibody(M4)
RA10398-100ul 100 ul
EUR 298

Cleaved PARP Mouse Monoclonal Antibody(M4)
RA10398-50ul 50 ul
EUR 198

Cleaved-PARP antibody
29033-100ul 100ul
EUR 302.4

Cleaved-PARP antibody
E18-7023-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

Cleaved-PARP antibody
E18-7023-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Cleaved-PARP Antibody
BF9106 200ul
EUR 540

Cleaved-PARP Antibody
BF9106-100ul 100ul
EUR 350

Cleaved-PARP Antibody
BF9106-200ul 200ul
EUR 450

Cleaved-PARP Antibody
BF9106-50ul 50ul
EUR 250

Poly ADP Ribose Polymerase Cleaved-Asp214 (PARP Cleaved-D214) Antibody
abx015613-1mg 1 mg
EUR 43.75

Poly ADP Ribose Polymerase Cleaved-Gly215 (PARP Cleaved-G215) Antibody
abx015614-1mg 1 mg
EUR 43.75

Cleaved PARP Mouse Monoclonal Antibody(Mix-mA™)
RA10406-100ul 100 ul
EUR 298

Cleaved PARP Mouse Monoclonal Antibody(Mix-mA™)
RA10406-50ul 50 ul
EUR 198

Rabbit polyclonal PARP (Cleaved-Asp214) antibody
TA326295 100 µl Ask for price

Rabbit polyclonal PARP (Cleaved-Gly215) antibody
TA313435 100 µl Ask for price

Cleaved-PARP (Asp214) Antibody
AF7023 200ul
EUR 540

Cleaved-PARP (Asp214) Antibody
AF7023-100ul 100ul
EUR 350

Cleaved-PARP (Asp214) Antibody
AF7023-200ul 200ul
EUR 450

Cleaved-PARP (Asp214) Antibody
AF7023-50ul 50ul
EUR 250

Monoclonal PARP-1 Antibody (Cleaved p85), Clone: Y34
APR08933G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PARP-1 (Cleaved p85). The antibodies are raised in Rabbit and are from clone Y34. This antibody is applicable in WB, FC

Monoclonal PARP-1 Antibody (Cleaved p25), Clone: E51
APR07143G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human PARP-1 (Cleaved p25). The antibodies are raised in Rabbit and are from clone E51. This antibody is applicable in WB, IHC and IF

Cleaved-PARP Conjugated Antibody
C29033 100ul
EUR 476.4

Cleaved PARP Rabbit pAb
E2380374 100ul
EUR 225
Description: Available in various conjugation types.

Cleaved PARP Rabbit pAb
E2380689 100ul
EUR 225
Description: Available in various conjugation types.

Cleaved PARP Rabbit mAb
58545 100ul
EUR 339

Cleaved PARP Rabbit mAb
58686 100ul
EUR 339

Cleaved-PARP (G215) Polyclonal Antibody
40519 100ul
EUR 319

Rabbit Polyclonal Cleaved-PARP antibody
TA325762 100 µl Ask for price

Cleaved PARP1 Antibody
E38PA9140 100ul
EUR 225
Description: Available in various conjugation types.

Cleaved PARP1 Antibody
20-abx133843
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Cleaved PARP1 Antibody
RQ5288 100ul
EUR 356.15
Description: The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. [Wiki] Cleavage of PARP, by enzymes such as caspases or cathepsins, typically inactivates PARP. While in vitro cleavage by caspase occurs throughout the caspase family, preliminary data suggest that caspase-3 and caspase-7 are responsible for in vivo cleavage. Cleavage occurs at aspartic acid 214 and glycine 215, separating PARP into a 24kDA and 89kDA segment. The smaller moiety includes the zinc finger motif requisite in DNA binding. The 89 kDa fragment includes the auto-modification domain and catalytic domain. [Wiki]

Cleaved PARP1 Antibody
RQ5289 100ul
EUR 356.15
Description: The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. [Wiki] Cleavage of PARP, by enzymes such as caspases or cathepsins, typically inactivates PARP. While in vitro cleavage by caspase occurs throughout the caspase family, preliminary data suggest that caspase-3 and caspase-7 are responsible for in vivo cleavage. Cleavage occurs at aspartic acid 214 and glycine 215, separating PARP into a 24kDA and 89kDA segment. The smaller moiety includes the zinc finger motif requisite in DNA binding. The 89 kDa fragment includes the auto-modification domain and catalytic domain. [Wiki]

Cleaved-PARP-1 (G215) Polyclonal Antibody
40519-100ul 100ul
EUR 302.4

Cleaved-PARP-1 (G215) Polyclonal Antibody
40519-50ul 50ul
EUR 224.4

Cleaved-PARP-1 (D214) Polyclonal Antibody
40520-100ul 100ul
EUR 302.4

Cleaved-PARP-1 (D214) Polyclonal Antibody
40520-50ul 50ul
EUR 224.4

Cleaved-PARP-1 (G215) Polyclonal Antibody
E040519 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Cleaved-PARP-1 (D214) Polyclonal Antibody
E040520 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Cleaved-PARP-1 (G215) Polyclonal Antibody
E20-10073 100ug
EUR 225
Description: Available in various conjugation types.

Cleaved-PARP-1 (D214) Polyclonal Antibody
E20-10101 100ug
EUR 225
Description: Available in various conjugation types.

Cleaved-PARP-1 (D214) Polyclonal Antibody
ABP0027-100uL 100 μL
EUR 229
Description: Rabbit Anti-Cleaved-PARP-1 (D214) Polyclonal Antibody

Cleaved-PARP-1 (G215) Polyclonal Antibody
ABP50053-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Cleaved-PARP-1 G215) from Human. This Cleaved-PARP-1 G215) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 170-250

Cleaved-PARP-1 (G215) Polyclonal Antibody
ABP50053-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Cleaved-PARP-1 G215) from Human. This Cleaved-PARP-1 G215) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 170-250

Cleaved-PARP-1 (G215) Polyclonal Antibody
ABP50053-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Cleaved-PARP-1 G215) from Human. This Cleaved-PARP-1 G215) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 170-250

Cleaved-PARP-1 (D214) Polyclonal Antibody
ABP50072-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Cleaved-PARP-1 D214) from Human, Mouse. This Cleaved-PARP-1 D214) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 140-220

Cleaved-PARP-1 (D214) Polyclonal Antibody
ABP50072-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Cleaved-PARP-1 D214) from Human, Mouse. This Cleaved-PARP-1 D214) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 140-220

Cleaved-PARP-1 (D214) Polyclonal Antibody
ABP50072-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Cleaved-PARP-1 D214) from Human, Mouse. This Cleaved-PARP-1 D214) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 140-220

Cleaved-PARP-1 (G215) Polyclonal Antibody
E44H00073 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Cleaved-PARP-1 (D214) Polyclonal Antibody
E44H00101 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Cleaved-PARP-1 (D214) Polyclonal Antibody
ABP0027-each each Ask for price

Cleaved-PARP-1 (D214) Polyclonal Antibody
ABP0027-Null Null Ask for price

PARP (Cleaved-Asp214) Rabbit pAb
E2618118 100ul
EUR 225
Description: Available in various conjugation types.

PARP-1 (Cleaved-D214) Rabbit pAb
E2340270 100ul
EUR 225
Description: Available in various conjugation types.

Cleaved PARP1 Monoclonal Antibody
E-AB-22074-120uL 120uL
EUR 240
Description: Unconjugated

Cleaved PARP1 Monoclonal Antibody
E-AB-22074-200uL 200uL
EUR 399
Description: Unconjugated

Cleaved PARP1 Monoclonal Antibody
E-AB-22074-20uL 20uL
EUR 73
Description: Unconjugated

Cleaved PARP1 Monoclonal Antibody
E-AB-22074-60uL 60uL
EUR 143
Description: Unconjugated

Cleaved-PARP-1 (G215) Rabbit Polyclonal Antibody
ES1052-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Cleaved-PARP-1 (G215) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cleaved-PARP-1 (G215) Rabbit Polyclonal Antibody
ES1052-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Cleaved-PARP-1 (G215) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cleaved-PARP-1 (D214) Rabbit Polyclonal Antibody
ES1071-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against Cleaved-PARP-1 (D214) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Cleaved-PARP-1 (D214) Rabbit Polyclonal Antibody
ES1071-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against Cleaved-PARP-1 (D214) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

[KO Validated] Cleaved PARP p25 Rabbit mAb
A19612-100ul 100 ul
EUR 492

[KO Validated] Cleaved PARP p25 Rabbit mAb
A19612-200ul 200 ul
EUR 685.2

[KO Validated] Cleaved PARP p25 Rabbit mAb
A19612-20ul 20 ul
EUR 265.2

[KO Validated] Cleaved PARP p25 Rabbit mAb
A19612-50ul 50 ul
EUR 344.4

Cleaved-PARP-1 (D214) Polyclonal Conjugated Antibody
C40520 100ul
EUR 476.4

Poly ADP-ribose polymerase 1 Cleaved-Asp214 (PARP1 Cleaved-D214) Antibody
abx325512-100g 100 µg
EUR 250

Poly ADP-ribose polymerase 1 Cleaved-Asp214 (PARP1 Cleaved-D214) Antibody
abx325512-50g 50 µg
EUR 187.5

Poly ADP-ribose polymerase 1 Cleaved-Gly215 (PARP1 Cleaved-G215) Antibody
abx324070-100g 100 µg
EUR 250

Poly ADP-ribose polymerase 1 Cleaved-Gly215 (PARP1 Cleaved-G215) Antibody
abx324070-50g 50 µg
EUR 187.5

PARP1(cleaved) Rabbit Polyclonal Antibody
E10G04413 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PARP1 (Cleaved) Rabbit Polyclonal Antibody
E10G29001 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Cleaved-PARP Blocking Peptide
AF7023-BP 1mg
EUR 234

Cleaved-PARP Blocking Peptide
BF9106-BP 1mg
EUR 234

anti- Cleaved LC3 antibody
FNab04716 100µg
EUR 606.3
Description: Antibody raised against Cleaved LC3

OAAQ00197-10T - Human PARP1 Antibody : PE (Cleaved-Asp214)
OAAQ00197-10T 10Tests
EUR 109

PARP1 (cleaved) rabbit polyclonal antibody, Aff - Purified
AP00048PU-N 100 µg Ask for price

PARP1 (cleaved) rabbit polyclonal antibody, Aff - Purified
AP00049PU-N 100 µg Ask for price

OAAQ00197-100T - Human PARP1 Antibody : PE (Cleaved-Asp214)
OAAQ00197-100T 100Tests
EUR 329

OAAQ00198-10T - Human PARP1 Antibody : APC (Cleaved-Asp214)
OAAQ00198-10T 10Tests
EUR 109

Kallikrein 11 Cleaved-Ile54 (Cleaved-I54) Antibody
abx323408-100g 100 µg
EUR 250

Kallikrein 11 Cleaved-Ile54 (Cleaved-I54) Antibody
abx323408-50g 50 µg
EUR 187.5

Kallikrein 8 Cleaved-Val33 (Cleaved-V33) Antibody
abx323501-100g 100 µg
EUR 250

Kallikrein 8 Cleaved-Val33 (Cleaved-V33) Antibody
abx323501-50g 50 µg
EUR 187.5

OAAQ00198-100T - Human PARP1 Antibody : APC (Cleaved-Asp214)
OAAQ00198-100T 100Tests
EUR 329

Neuropsin Cleaved-Val33 (OPN5 Cleaved-V33) Antibody
abx015610-1mg 1 mg
EUR 43.75

Plasminogen Cleaved-Val98 (PLG Cleaved-V98) Antibody
abx327333-100g 100 µg
EUR 250

Plasminogen Cleaved-Val98 (PLG Cleaved-V98) Antibody
abx327333-50g 50 µg
EUR 187.5

PAR1 (Cleaved-Ser42) Antibody
E11-0374L 100μg
EUR 225
Description: Available in various conjugation types.

PAR4 (Cleaved-Gly48) Antibody
E11-0377L 100μg
EUR 225
Description: Available in various conjugation types.

PAR1 (Cleaved-Ser42) Antibody
8L0374 50ug
EUR 368
Description: PAR1 (Cleaved-Ser42) Antibody

PAR4 (Cleaved-Gly48) Antibody
8L0377 50ug
EUR 368
Description: PAR4 (Cleaved-Gly48) Antibody

PAR1 (Cleaved-Ser42) Antibody
20-abx015616
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

PAR4 (Cleaved-Gly48) Antibody
20-abx015617
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

RB cleaved Antibody
GWB-722CA1 0.05 mg Ask for price

Lamin A Cleaved-Asp230 (LMNA Cleaved-D230) Antibody
abx015542-10mg 10 mg
EUR 312.5

Lamin A Cleaved-Asp230 (LMNA Cleaved-D230) Antibody
abx015542-1mg 1 mg
EUR 43.75

Lamin A Cleaved-Asp230 (LMNA Cleaved-D230) Antibody
abx015542-5mg 5 mg
EUR 237.5

Lamin A Cleaved-Asp230 (LMNA Cleaved-D230) Antibody
abx015543-1mg 1 mg
EUR 43.75

Myeloperoxidase Cleaved-Ala49 (MPO Cleaved-A49) Antibody
abx323504-100g 100 µg
EUR 250

Myeloperoxidase Cleaved-Ala49 (MPO Cleaved-A49) Antibody
abx323504-50g 50 µg
EUR 187.5

Caspase 3 Cleaved-Ser29 (CASP3 Cleaved-S29) Antibody
abx015556-1mg 1 mg
EUR 43.75

Caspase 4 Cleaved-Gln81 (CASP4 Cleaved-Q81) Antibody
abx324639-100g 100 µg
EUR 250

Caspase 4 Cleaved-Gln81 (CASP4 Cleaved-Q81) Antibody
abx324639-50g 50 µg
EUR 187.5

Cleaved LC3 antibody
E39-04716 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Cleaved LC3 antibody
CAF50567-100ug 100ug
EUR 312

CD97 Antigen Cleaved-Leu530 (ADGRE5 Cleaved-L530) Antibody
abx324040-100g 100 µg
EUR 250

CD97 Antigen Cleaved-Leu530 (ADGRE5 Cleaved-L530) Antibody
abx324040-50g 50 µg
EUR 187.5

CD97 Antigen Cleaved-Ser531 (ADGRE5 Cleaved-S531) Antibody
abx324041-100g 100 µg
EUR 250

CD97 Antigen Cleaved-Ser531 (ADGRE5 Cleaved-S531) Antibody
abx324041-50g 50 µg
EUR 187.5

Cathepsin Z Cleaved-Leu62 (CTSZ Cleaved-L62) Antibody
abx015570-1mg 1 mg
EUR 43.75

Ephrin A2 Cleaved-Asn188 (EFNA2 Cleaved-N188) Antibody
abx015587-1mg 1 mg
EUR 43.75

Cathepsin D Cleaved-Gly65 (CTSD Cleaved-G65) Antibody
abx325029-100g 100 µg
EUR 250

Cathepsin D Cleaved-Gly65 (CTSD Cleaved-G65) Antibody
abx325029-50g 50 µg
EUR 187.5

Cathepsin Z Cleaved-Leu62 (CTSZ Cleaved-L62) Antibody
abx325049-100g 100 µg
EUR 250

Cathepsin Z Cleaved-Leu62 (CTSZ Cleaved-L62) Antibody
abx325049-50g 50 µg
EUR 187.5

Integrin Alpha 5 Cleaved-Phe42 (Cleaved-F42) Antibody
abx325454-100g 100 µg
EUR 250

Integrin Alpha 5 Cleaved-Phe42 (Cleaved-F42) Antibody
abx325454-50g 50 µg
EUR 187.5

Ephrin A2 Cleaved-Asn188 (EFNA2 Cleaved-N188) Antibody
abx325473-100g 100 µg
EUR 250

Ephrin A2 Cleaved-Asn188 (EFNA2 Cleaved-N188) Antibody
abx325473-50g 50 µg
EUR 187.5

Cathepsin G Cleaved-Ile21 (CTSG Cleaved-I21) Antibody
abx327697-100g 100 µg
EUR 250

The purpose of this evaluation is to overview the rising knowledge within the literature exhibiting the function of PARP within the pathogenesis of most cancers and inflammatory illnesses and unravel the strong physique of literature that helps the view that PARP is a vital goal for therapeutic intervention in important sickness.

By Connie StoneTags: , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,