Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.


Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.

Impaired DNA harm response pathways might create vulnerabilities of most cancers cells that may be exploited therapeutically. One such selective vulnerability is the sensitivity of BRCA1- or BRCA2-defective tumors (therefore faulty in DNA restore by homologous recombination, HR) to inhibitors of the poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme important for restore pathways various to HR. Whereas promising, remedy with PARP-1 inhibitors (PARP-1i) faces some hurdles, together with (1) acquired resistance, (2) seek for different sensitizing, non-BRCA1/2 most cancers defects and (3) lack of biomarkers to foretell response to PARP-1i.

Right here we addressed these points utilizing PARP-1i on 20 human cell traces from carcinomas of the breast, prostate, colon, pancreas and ovary. Aberrations of the Mre11-Rad50-Nbs1 (MRN) advanced sensitized most cancers cells to PARP-1i, whereas p53 standing was much less predictive, even in response to PARP-1i combos with camptothecin or ionizing radiation. Moreover, monitoring PARsylation and Rad51 foci formation as surrogate markers for PARP exercise and HR, respectively, supported their candidacy for biomarkers of PARP-1i responses. As to resistance mechanisms, we confirmed the function of the multidrug resistance efflux transporters and its reversibility.

Extra importantly, we demonstrated that shRNA lentivirus-mediated depletion of 53BP1 in human BRCA1-mutant breast most cancers cells elevated their resistance to PARP-1i. Given the preferential lack of 53BP1 in BRCA-defective and triple-negative breast carcinomas, our findings warrant evaluation of 53BP1 amongst candidate predictive biomarkers of response to PARPi. Total, this research helps characterize genetic and purposeful determinants of mobile responses to PARP-1i and contributes to the seek for biomarkers to take advantage of PARP inhibitors in most cancers remedy.

Since many anti-cancer brokers act by inflicting DNA harm on tumour cells, there may be rising curiosity in the usage of inhibitors of DNA restore to extend the cytotoxicity of those brokers. Poly(ADP-ribose) polymerase (PARP) is an ample nuclear enzyme that binds to websites of DNA harm and promotes restore by modifying quite a lot of key proteins. Potent and particular inhibitors of PARP can be found; these have been proven to extend the cytotoxicity of a variety of anti-cancer brokers together with temozolomide, irinotecan and radiation. The PARP pathway and its inhibition thus provides quite a lot of alternatives for therapeutic intervention in each most cancers and different illness states.

Evaluate of poly (ADP-ribose) polymerase (PARP) mechanisms of motion and rationale for focusing on in most cancers and different illnesses.

Poly (ADP-ribose) polymerases (PARPs) are a household of associated enzymes that share the flexibility to catalyze the switch of ADP-ribose to focus on proteins. PARPs play an essential function in numerous mobile processes, together with modulation of chromatin construction, transcription, replication, recombination, and DNA restore. The function of PARP proteins in DNA restore is of explicit curiosity, in view of the discovering that sure tumors faulty in homologous recombination mechanisms, might depend on PARP-mediated DNA restore for survival, and are delicate to its inhibition. PARP inhibitors can also improve tumor sensitivity to DNA-damaging brokers.

Medical trials of PARP inhibitors are investigating the utility of those approaches in most cancers. The hyperactivation of PARP has additionally been proven to lead to a selected programmed cell demise pathway involving NAD+/ATP depletion, mu-calpain activation, lack of mitochondrial membrane potential, and the discharge of apoptosis inducing issue. Hyperactivation of the PARP pathway could also be exploited to selectively kill most cancers cells. Different PARP varieties, together with tankyrase 1 (PARP 5a), which performs an essential function in enhancing telomere elongation by telomerase, have been discovered to be potential targets in most cancers remedy.

Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.

PARP inhibitors: new companions within the remedy of most cancers and inflammatory illnesses.

Poly(ADP-ribose) polymerases (PARPs) are outlined as cell signaling enzymes that catalyze the switch of ADP-ribose items from NAD(+) to quite a lot of acceptor proteins. PARP-1, the very best characterised member of the PARP household, which presently contains 18 members, is an ample nuclear enzyme implicated in mobile responses to DNA harm provoked by genotoxic stress. PARP is concerned in DNA restore and transcriptional regulation and is now acknowledged as a key regulator of cell survival and cell demise in addition to a grasp part of quite a lot of transcription elements concerned in tumor growth and irritation.

PARP-1 is important to the restore of DNA single-strand breaks through the bottom excision restore pathway. Inhibitors of PARP-1 have been proven to reinforce the cytotoxic results of ionizing radiation and DNA-damaging chemotherapy brokers, such because the methylating brokers and topoisomerase I inhibitors. There are presently at the very least 5 PARP inhibitors in medical trial growth. Latest in vitro and in vivo proof means that PARP inhibitors may very well be used not solely as chemo/radiotherapy sensitizers, but additionally as single brokers to selectively kill cancers faulty in DNA restore,

particularly cancers with mutations within the breast cancer-associated genes (BRCA1 and BRCA2). PARP turns into activated in response to oxidative DNA harm and depletes mobile power swimming pools, thus resulting in mobile dysfunction in numerous tissues. The activation of PARP can also induce numerous cell demise processes and promotes an inflammatory response related to a number of organ failure. Inhibition of PARP exercise is protecting in a variety of inflammatory and ischemia-reperfusion-associated illnesses, together with cardiovascular illnesses, diabetes, rheumatoid arthritis, endotoxic shock, and stroke.

Cleaved-PARP antibody

29033-100ul 100ul
EUR 252

PARP (Cleaved) Antibody

3140-100
EUR 468

PARP (Cleaved) Antibody

3141-100
EUR 446

Cleaved PARP Antibody

48805-100ul 100ul
EUR 333

Cleaved PARP Antibody

48805-50ul 50ul
EUR 239

Cleaved PARP Antibody

abx020094-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

Cleaved-PARP Antibody

AF7023 200ul
EUR 376
Description: PARP (Cleaved-Asp214) Antibody detects endogenous levels of fragment of activated PARP resulting from cleavage adjacent to Asp214.

Cleaved-PARP Antibody

BF9106 200ul
EUR 376
Description: The Cleaved PARP Mouse mAb can recognize endogenous pro and active PARP proteins.

Cleaved- PARP antibody

ABF7023 100 ug
EUR 438

Anti-Cleaved PARP Rabbit Monoclonal Antibody

M00122-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Cleaved PARP Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Cleaved PARP Rabbit Monoclonal Antibody

M00122-2 100ug/vial
EUR 397
Description: Rabbit Monoclonal Cleaved PARP Antibody. Validated in Flow Cytometry, IP, IF, ICC, WB and tested in Human.

Anti-Cleaved-PARP-1 (G215) antibody

STJ90072 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-PARP-1 (G215).

Anti-Cleaved-PARP-1 (D214) antibody

STJ90100 200 µl
EUR 197
Description: Cleaved-PARP-1 is a protein encoded by the PARP1 gene which is approximately 113 kDa. Cleaved-PARP-1 is localised to the nucleus. It is involved in telomere C-strand synthesis, transcription-coupled nucleotide excision repair and survival caspase cascades. It is a chromatin-associated enzyme, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is DNA dependent and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation. It also pays a role in the regulation of the molecular events involved in the recovery of cell from DNA damage. Cleaved-PARP-1 is expressed in the nervous system, liver, intestine, lung and eye. Mutations in the PARP1 gene may result in diphtheria and hemorrhagic cystitis. The antibody STJ90100 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment activated PARP-1 protein resulting from cleavage adjacent to D214.

PARP (Cleaved-Asp214) Antibody

20-abx015613
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

PARP (Cleaved-Gly215) Antibody

20-abx015614
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Cleaved-PARP Conjugated Antibody

C29033 100ul
EUR 397

Polyclonal PARP (Cleaved) Antibody

APR08927G 0.1mg
EUR 528
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PARP (Cleaved) . This antibody is tested and proven to work in the following applications:

Cleaved PARP Monoclonal Antibody

ABM40132-003ml 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40132-01ml 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40132-02ml 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40145-003ml 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40145-01ml 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

ABM40145-02ml 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of Cleaved PARP from Human. This Cleaved PARP antibody is for WB, IF, IHC-P. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Cleaved PARP Monoclonal Antibody

EM1132-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Monoclonal Antibody

EM1132-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Monoclonal Antibody

EM1145-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Monoclonal Antibody

EM1145-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against Cleaved PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

Cleaved PARP Mouse Monoclonal Antibody

38068-100ul 100ul
EUR 252

Cleaved PARP Mouse Monoclonal Antibody

38068-50ul 50ul
EUR 187

Cleaved PARP Mouse Monoclonal Antibody

38076-100ul 100ul
EUR 252

Cleaved PARP Mouse Monoclonal Antibody

38076-50ul 50ul
EUR 187

Polyclonal Cleaved PARP (Asp214) Antibody

APG02631G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cleaved PARP (Asp214) . This antibody is tested and proven to work in the following applications:

Cleaved PARP recombinant monoclonal antibody

A5034 100ul X 3
EUR 595
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
  • Show more
Description: A recombinant monoclonal antibody from rabbit against human Cleaved PARP for WB,ELISA

Cleaved-PARP Blocking Peptide

AF7023-BP 1mg
EUR 195

Cleaved-PARP Blocking Peptide

BF9106-BP 1mg
EUR 195

Cleaved-PARP-1 (G215) Polyclonal Antibody

40519-100ul 100ul
EUR 252

Cleaved-PARP-1 (G215) Polyclonal Antibody

40519-50ul 50ul
EUR 187

Cleaved-PARP-1 (D214) Polyclonal Antibody

40520-100ul 100ul
EUR 252

Cleaved-PARP-1 (D214) Polyclonal Antibody

40520-50ul 50ul
EUR 187

Cleaved-PARP-1 (G215) Polyclonal Antibody

ABP50053-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-1 at AA range: 170-250
  • Applications tips:
Description: A polyclonal antibody for detection of Cleaved-PARP-1 G215) from Human. This Cleaved-PARP-1 G215) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 170-250

Cleaved-PARP-1 (G215) Polyclonal Antibody

ABP50053-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-1 at AA range: 170-250
  • Applications tips:
Description: A polyclonal antibody for detection of Cleaved-PARP-1 G215) from Human. This Cleaved-PARP-1 G215) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 170-250

Cleaved-PARP-1 (G215) Polyclonal Antibody

ABP50053-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-1 at AA range: 170-250
  • Applications tips:
Description: A polyclonal antibody for detection of Cleaved-PARP-1 G215) from Human. This Cleaved-PARP-1 G215) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 170-250

Cleaved-PARP-1 (D214) Polyclonal Antibody

ABP50072-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-1 at AA range: 140-220
  • Applications tips:
Description: A polyclonal antibody for detection of Cleaved-PARP-1 D214) from Human, Mouse. This Cleaved-PARP-1 D214) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 140-220

Cleaved-PARP-1 (D214) Polyclonal Antibody

ABP50072-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-1 at AA range: 140-220
  • Applications tips:
Description: A polyclonal antibody for detection of Cleaved-PARP-1 D214) from Human, Mouse. This Cleaved-PARP-1 D214) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 140-220

Cleaved-PARP-1 (D214) Polyclonal Antibody

ABP50072-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human PARP-1 at AA range: 140-220
  • Applications tips:
Description: A polyclonal antibody for detection of Cleaved-PARP-1 D214) from Human, Mouse. This Cleaved-PARP-1 D214) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human PARP-1 at AA range: 140-220

Cleaved-PARP-1 (D214) Polyclonal Antibody

ES1071-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Cleaved-PARP-1 (D214) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Cleaved-PARP-1 (D214) Polyclonal Antibody

ES1071-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Cleaved-PARP-1 (D214) from Human/Mouse. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Cleaved-PARP-1 (G215) Polyclonal Antibody

ES1052-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Cleaved-PARP-1 (G215) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cleaved-PARP-1 (G215) Polyclonal Antibody

ES1052-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Cleaved-PARP-1 (G215) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cleaved-PARP-1 (D214) Polyclonal Conjugated Antibody

C40520 100ul
EUR 397

Anti-PARP antibody

STJ97033 200 µl
EUR 197
Description: Mouse monoclonal to PARP.

Monoclonal PARP-1 Antibody (Cleaved p25), Clone: E51

APR07143G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human PARP-1 (Cleaved p25). The antibodies are raised in Rabbit and are from clone E51. This antibody is applicable in WB, IHC and IF

Monoclonal PARP-1 Antibody (Cleaved p85), Clone: Y34

APR08933G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human PARP-1 (Cleaved p85). The antibodies are raised in Rabbit and are from clone Y34. This antibody is applicable in WB, FC

[KO Validated] Cleaved PARP p25 Rabbit mAb

A19612-100ul 100 ul
EUR 410

[KO Validated] Cleaved PARP p25 Rabbit mAb

A19612-200ul 200 ul
EUR 571

[KO Validated] Cleaved PARP p25 Rabbit mAb

A19612-20ul 20 ul
EUR 221

[KO Validated] Cleaved PARP p25 Rabbit mAb

A19612-50ul 50 ul
EUR 287

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-PARP-2 Antibody

A03270-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for PARP-2 Antibody (PARP2) detection. Tested with WB in Human, Mouse.

Anti-PARP-3 Antibody

A03762 100ul
EUR 522
Description: Rabbit Polyclonal PARP-3 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse.

Anti-PARP-1 Antibody

A00122-1 100ul
EUR 397
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse.

Anti-PARP/PARP1 Antibody

PA2227 100ug/vial
EUR 294

Anti-PARP/PARP1 Antibody

PB9309 100ug/vial
EUR 334

Anti-PARP-2 antibody

STJ94959 200 µl
EUR 197
Description: Rabbit polyclonal to PARP-2.

Anti-PARP-3 antibody

STJ94960 200 µl
EUR 197
Description: Rabbit polyclonal to PARP-3.

Anti-PARP-4 antibody

STJ94961 200 µl
EUR 197
Description: Rabbit polyclonal to PARP-4.

Anti-PARP-1 antibody

STJ97648 200 µl
EUR 197
Description: Rabbit polyclonal to PARP-1.

anti-PARP (M3)

LF-MA20421 100 ug
EUR 354
Description: Mouse monoclonal to PARP

anti-PARP (7A10)

LF-MA30362 100 ul
EUR 486
Description: Mouse Monoclonal to PARP

Anti-PARP (3G4)

YF-MA10018 100 ug
EUR 363
Description: Mouse monoclonal to PARP

Anti-PARP (2C7)

YF-MA11839 50 ug
EUR 363
Description: Mouse monoclonal to PARP

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

DLR-PARP-Hu-48T 48T
EUR 479
  • Should the Human Poly ADP Ribose Polymerase (PARP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase (PARP) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

DLR-PARP-Hu-96T 96T
EUR 621
  • Should the Human Poly ADP Ribose Polymerase (PARP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase (PARP) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit

DLR-PARP-Mu-48T 48T
EUR 527
  • Should the Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Poly ADP Ribose Polymerase (PARP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit

DLR-PARP-Mu-96T 96T
EUR 688
  • Should the Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Poly ADP Ribose Polymerase (PARP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

RDR-PARP-Hu-48Tests 48 Tests
EUR 500

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

RDR-PARP-Hu-96Tests 96 Tests
EUR 692

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit

RDR-PARP-Mu-48Tests 48 Tests
EUR 557

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit

RDR-PARP-Mu-96Tests 96 Tests
EUR 774

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

RD-PARP-Hu-48Tests 48 Tests
EUR 478

Human Poly ADP Ribose Polymerase (PARP) ELISA Kit

RD-PARP-Hu-96Tests 96 Tests
EUR 662

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit

RD-PARP-Mu-48Tests 48 Tests
EUR 533

Mouse Poly ADP Ribose Polymerase (PARP) ELISA Kit

RD-PARP-Mu-96Tests 96 Tests
EUR 740

Anti-PARP Rabbit Monoclonal Antibody

M00122 100ug/vial
EUR 397
Description: Rabbit Monoclonal PARP Antibody. Validated in IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Anti-PARP Rabbit Monoclonal Antibody

M00122-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal PARP Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Anti-PARP-1 antibody (KLH)

STJ98308 100 µl
EUR 234
Description: Mouse monoclonal to PARP-1 (KLH).

PARP Antibody

3002-100
EUR 316

PARP Antibody

3002-30T
EUR 146

PARP antibody

20R-1423 100 ug
EUR 673
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-11555 100 ug
EUR 404
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-11640 100 ug
EUR 611
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-11641 100 ug
EUR 581
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-30801 100 ug
EUR 327
Description: Rabbit polyclonal PARP antibody

PARP antibody

70R-30803 100 ug
EUR 327
Description: Rabbit polyclonal PARP antibody

PARP antibody

10R-2170 100 ul
EUR 403
Description: Mouse monoclonal PARP antibody

PARP antibody

10R-8001 100 ul
EUR 503
Description: Mouse monoclonal PARP antibody

PARP antibody

10R-8057 100 ug
EUR 470
Description: Mouse polyclonal PARP antibody

PARP Antibody

48838-100ul 100ul
EUR 333

PARP Antibody

48838-50ul 50ul
EUR 239

PARP antibody

BF0719 200ul
EUR 376
Description: PARP mouse monoclonal antibody detects endogenous levels of total PPAR.

anti- Cleaved LC3 antibody

FNab04716 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500 - 1:2000
  • IHC: 1:50 - 1:200
  • Immunogen: microtubule-associated protein 1 light chain 3 alpha
  • Uniprot ID: Q9H492
  • Gene ID: 84557
  • Research Area: Neuroscience, Cardiovascular, Metabolism
Description: Antibody raised against Cleaved LC3

Anti-PARP-1 (Acetyl K521) antibody

STJ98846 200 µl
EUR 197
Description: Rabbit polyclonal to E2F-1.

Anti-Cleaved-COL1A2 (G1102) Antibody

A00624 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cleaved-COL1A2 (G1102) Antibody (COL1A2) detection. Tested with WB in Human.

Anti-cleaved-caspase 3 antibody

PAab01290 100 ug
EUR 386

Anti-Cleaved-Aggrecan (D369) antibody

STJ90041 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Aggrecan (D369).

Anti-Cleaved-Bad (D71) antibody

STJ90042 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Bad (D71).

Anti-Cleaved-COL1A2 (G1102) antibody

STJ90048 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-COL1A2 (G1102).

Anti-Cleaved-COL3A1 (G1221) antibody

STJ90049 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-COL3A1 (G1221).

Anti-Cleaved-COL4A3 (L1425) antibody

STJ90050 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-COL4A3 (L1425).

Anti-Cleaved-KLK11 (I54) antibody

STJ90054 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-KLK11 (I54).

Anti-Cleaved-KLK8 (V33) antibody

STJ90055 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-KLK8 (V33).

Anti-Cleaved-TACE (R215) antibody

STJ90075 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-TACE (R215).

Anti-Cleaved-Tumstatin (P1426) antibody

STJ90077 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Tumstatin (P1426).

Anti-Cleaved-PAR1 (Ser42) antibody

STJ99660 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-PAR1 (Ser42).

Polyclonal PARP Antibody

APR08928G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human PARP . This antibody is tested and proven to work in the following applications:

PARP Monoclonal Antibody

ABM40131-003ml 0.03ml
EUR 158
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PARP Monoclonal Antibody

ABM40131-01ml 0.1ml
EUR 289
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PARP Monoclonal Antibody

ABM40131-02ml 0.2ml
EUR 414
  • Immunogen information: Synthetic Peptide
  • Applications tips:
Description: A monoclonal antibody for detection of PARP from Human. This PARP antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PARP Monoclonal Antibody

EM1131-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

PARP Monoclonal Antibody

EM1131-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against PARP from Human. This antibody is tested and validated for WB, ELISA, IHC

PARP/ Rat PARP ELISA Kit

ELA-E0947r 96 Tests
EUR 886

Anti-Cleaved-ITI-H2 (D702) Antibody

A07196 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cleaved-ITI-H2 (D702) Antibody (ITIH2) detection. Tested with WB in Human.

Anti-Cleaved-MMP-17 (Q129) Antibody

A08090 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cleaved-MMP-17 (Q129) Antibody (MMP17) detection. Tested with WB, ELISA in Human.

Anti-Cleaved-Cathepsin L2 (L114) Antibody

A09374 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cleaved-Cathepsin L2 (L114) Antibody (CTSV) detection. Tested with WB in Human, Monkey.

Anti-Cleaved-MMP-27 (Y99) Antibody

A11153 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cleaved-MMP-27 (Y99) Antibody (MMP27) detection. Tested with WB in Human, Monkey.

Anti-Notch 1 (Cleaved-Val1744) Antibody

A1619-100
EUR 479

Anti-Caspase-7 (active/cleaved) Antibody

A01044 50 ul
EUR 397
Description: Rabbit Polyclonal Caspase-7 (active/cleaved) Antibody. Validated in IP, WB and tested in Human, Mouse, Rat.

Anti-Cleaved-Notch 1 (V1754) Antibody

A00033-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Cleaved-Notch 1 (V1754) Antibody (NOTCH1) detection.tested for WB in Human, Mouse, Rat.

Anti-Cleaved-Caspase-1 (D210) antibody

STJ90001 200 µl
EUR 197
Description: Caspase-1 is a protein encoded by the CASP1 gene which is approximately 45,1 kDa. Caspase-1 is localised to the cytoplasm. It is involved in amyotrophic lateral sclerosis, toll-like receptor signalling pathways, p53 signalling and the TNFR1 pathway. This protein falls under the the cysteine-aspartic acid protease family. upon activation It plays a central role in the execution-phase of cell apoptosis. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules. Caspase-1 is expressed mainly in the spleen and lung. Mutations in the CASP1 gene may result in shigellosis and cowpox. STJ90001 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment activated Caspase-1 protein resulting from cleavage adjacent to D210.

Anti-Cleaved-Caspase-1 (M211) antibody

STJ90002 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Caspase-1 (M211).

Anti-Cleaved-Caspase-7 (S199) antibody

STJ90009 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Caspase-7 (S199).

Anti-Cleaved-Caspase-8 (D384) antibody

STJ90010 200 µl
EUR 197
Description: Caspase-8 is a protein encoded by the CASP8 gene which is approximately 55,3 kDa. Caspase-8 is localised to the cytoplasm and is involved in the TNFR1 pathway, dimerization of procaspase-8 , activated TLR4 signalling, apoptosis signalling and toll-like receptor signalling pathways. This protein falls under the cysteine-aspartic acid protease family. It pays a role in the programmed cell death induced by Fas and various apoptotic stimuli. Caspase-8 isoform 1, 5 and 7 are expressed in a wide variety of tissues. Mutations in the CASP8 gene may result in a caspase-8 deficiency. STJ90010 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment activated Caspase-8 p18 protein resulting from cleavage adjacent to D384.

Anti-Cleaved-Caspase-9 (D353) antibody

STJ90011 200 µl
EUR 197
Description: Caspase-9 is a protein encoded by the CASP9 gene which is approximately 46,2 kDa. Caspase-9 is localised to the cytosol, mitochondrion and nucleus. It is involved in the TNFR1 pathway, RET signalling and apoptosis modulation and signalling. Caspase-9 exist as an inactive proenzyme which undergoes proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. It is involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase-9 is ubiquitously expressed with highest expression in the heart. Mutations in the CASP9 gene may result in cerebral hypoxia and cervical cancer. STJ90011 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment activated Caspase-9 protein resulting from cleavage adjacent to D353._x000D_

Anti-Cleaved-Caspase-9 (D330) antibody

STJ90012 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Caspase-9 (D330).

Anti-Cleaved-C1r HC (R463) antibody

STJ90017 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-C1r HC (R463).

Anti-Cleaved-C1r LC (I464) antibody

STJ90018 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-C1r LC (I464).

Anti-Cleaved-C1s HC (R437) antibody

STJ90019 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-C1s HC (R437).

Anti-Cleaved-Cathepsin G (I21) antibody

STJ90043 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Cathepsin G (I21).

Anti-Cleaved-Cathepsin L2 (L114) antibody

STJ90044 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Cathepsin L2 (L114).

Anti-Cleaved-Cathepsin Z (L62) antibody

STJ90045 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Cathepsin Z (L62).

Anti-Cleaved-CD9 alpha (L530) antibody

STJ90046 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-CD97alpha (L530).

Anti-Cleaved-CD9 beta (S531) antibody

STJ90047 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-CD97beta (S531).

Anti-Cleaved-Ephrin-A2 (N188) antibody

STJ90051 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Ephrin-A2 (N188).

Anti-Cleaved-Factor XIIIa (G39) antibody

STJ90052 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Factor XIIIa (G39).

Anti-Cleaved-Lamin A (D230) antibody

STJ90056 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Lamin A (D230).

Anti-Cleaved-Lamin A (N231) antibody

STJ90057 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Lamin A (N231).

Anti-Cleaved-MMP-10 (F99) antibody

STJ90058 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-MMP-10 (F99).

Anti-Cleaved-MMP-12 (G106) antibody

STJ90059 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-MMP-12 (G106).

Anti-Cleaved-MMP-14 (Y112) antibody

STJ90060 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-MMP-14 (Y112).

Anti-Cleaved-MMP-15 (Y132) antibody

STJ90061 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-MMP-15 (Y132).

Anti-Cleaved-MMP-17 (Q129) antibody

STJ90062 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-MMP-17 (Q129).

Anti-Cleaved-MMP-23 (Y79) antibody

STJ90063 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-MMP-23 (Y79).

Anti-Cleaved-MMP-27 (Y99) antibody

STJ90064 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-MMP-27 (Y99).

Anti-Cleaved-MMP-3 (F100) antibody

STJ90065 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-MMP-3 (F100).

Anti-Cleaved-Notch 1 (V1754) antibody

STJ90066 200 µl
EUR 197
Description: Notch 1 is a protein encoded by the NOTCH1 gene which is approximately 272,5 kDa. Notch 1 is localised to the cell membrane. It is involved in the notch signalling pathway and Notch 2 activation and transmission of signal to the nucleus. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch 1 is expressed in most adult tissues but is found mainly in lymphoid tissues. Mutations in the NOTCH1 gene may result in aortic valve disease and Adams-Oliver syndrome. STJ90066 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment of activated Notch 1 protein resulting from cleavage adjacent to V1754.

Anti-Cleaved-Notch 2 (A1734) antibody

STJ90067 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Notch 2 (A1734).

Anti-Cleaved-Notch 2 (D1733) antibody

STJ90068 200 µl
EUR 197
Description: Cleaved-Notch 2 is a protein encoded by the NOTCH2 gene which is approximately 265,4 kDa. Cleaved-Notch 2 is localised to the cell membrane, cytoplasm and nucleus. It is involved in the notch signalling pathway, glioma and diseases of glycosylation. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Cleaved-Notch 2 is expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Mutations in the NOTCH2 gene may result in Alagille syndrome. STJ90068 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment activated Notch 2 protein resulting from cleavage adjacent to D1733.

Anti-Cleaved-Notch 2 (V1697) antibody

STJ90069 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Notch 2 (V1697).

Anti-Cleaved-Notch 4 (V1432) antibody

STJ90070 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Notch 4 (V1432).

Anti-Cleaved-PAR-4 (G48) antibody

STJ90071 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-PAR-4 (G48).

Anti-Cleaved-Thrombin APII (R327) antibody

STJ90076 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Thrombin APII (R327).

Anti-Cleaved-GGT4 HC (T472) antibody

STJ90085 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-GGT4 HC (T472).

Anti-Cleaved-ITI-H1 (D672) antibody

STJ90092 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-ITI-H1 (D672).

Anti-Cleaved-ITI-H2 (D702) antibody

STJ90093 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-ITI-H2 (D702).

Anti-Cleaved-MPO 89k (A49) antibody

STJ90099 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-MPO 89k (A49).

The purpose of this evaluation is to overview the rising knowledge within the literature exhibiting the function of PARP within the pathogenesis of most cancers and inflammatory illnesses and unravel the strong physique of literature that helps the view that PARP is a vital goal for therapeutic intervention in important sickness.

September 2021
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