Cells which might be poor in homologous recombination, resembling people who lack useful breast cancer-associated 1 (BRCA1) or BRCA2, are hypersensitive to inhibition of poly(ADP-ribose) polymerase (PARP). Nevertheless, BRCA-deficient tumors symbolize solely a small fraction of grownup cancers, which could limit the therapeutic utility of PARP inhibitor monotherapy. Cyclin-dependent kinase 1 (Cdk1) phosphorylates BRCA1, and that is important for environment friendly formation of BRCA1 foci. Right here we present that depletion or inhibition of Cdk1 compromises the power of cells to restore DNA by homologous recombination.
Mixed inhibition of Cdk1 and PARP in BRCA-wild-type most cancers cells resulted in decreased colony formation, delayed progress of human tumor xenografts and tumor regression with extended survival in a mouse mannequin of lung adenocarcinoma. Inhibition of Cdk1 didn’t sensitize nontransformed cells or tissues to inhibition of PARP. As a result of decreased Cdk1 exercise impaired BRCA1 operate and consequently, restore by homologous recombination, inhibition of Cdk1 represents a believable technique for increasing the utility of PARP inhibitors to BRCA-proficient cancers.
Ewing’s sarcoma household of tumors (ESFT) refers to aggressive malignancies which steadily harbor attribute EWS-FLI1 or EWS-ERG genomic fusions. Right here, we report that these fusion merchandise work together with the DNA harm response protein and transcriptional coregulator PARP-1. ESFT cells, major tumor xenografts, and tumor metastases had been all extremely delicate to PARP1 inhibition. Addition of a PARP1 inhibitor to the second-line chemotherapeutic agent temozolamide resulted in full responses of all handled tumors in an EWS-FLI1-driven mouse xenograft mannequin of ESFT.
Mechanistic investigations revealed that DNA harm induced by expression of EWS-FLI1 or EWS-ERG fusion genes was potentiated by PARP1 inhibition in ESFT cell strains. Notably, EWS-FLI1 fusion genes acted in a optimistic suggestions loop to take care of the expression of PARP1, which was required for EWS-FLI-mediated transcription, thereby implementing oncogene-dependent sensitivity to PARP-1 inhibition. Collectively, our findings provide a robust preclinical rationale to focus on the EWS-FLI1:PARP1 intersection as a therapeutic technique to enhance the therapy of ESFTs.
PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies.
Poly(ADP-ribose)polymerase inhibitors (PARPis) have proven promising exercise in sufferers with BRCA1/2 mutation-associated (BRCA1/2(MUT+)) ovarian and breast cancers. Accumulating proof means that PARPi could have a wider software within the therapy of sporadic high-grade serous ovarian most cancers, and cancers faulty in DNA restore pathways, resembling prostate, endometrial, and pancreatic cancers. A number of PARPis are at present in section 1/2 scientific investigation, with registration trials now being designed.
Olaparib, probably the most studied PARPis, has demonstrated exercise in BRCA1/2(MUT+) and BRCA-like sporadic ovarian and breast cancers, and appears promising in prostate and pancreatic cancers. Understanding extra in regards to the molecular abnormalities concerned in BRCA-like tumors, exploring novel therapeutic trial methods and drug combos, and defining potential predictive biomarkers, is crucial to quickly advancing the sector of PARPi remedy and enhance scientific outcomes.
Using the idea of artificial lethality has supplied new alternatives for the event of focused therapies, by permitting the focusing on of lack of operate genetic aberrations. In most cancers cells with BRCA1 or BRCA2 lack of operate, which harbor deficiency of DNA restore by homologous recombination, inhibition of PARP1 enzymatic exercise results in an accumulation of single strand breaks which might be transformed to double strand breaks however can’t be repaired by homologous recombination. Inhibition of PARP has subsequently been superior as a novel focused remedy for cancers harboring BRCA1/2 mutations.
PARP inhibitors for most cancers remedy.
Poly(ADP-ribose) polymerase 1 (PARP-1) is a zinc-finger DNA-binding enzyme that’s activated by binding to DNA breaks. Poly(ADP-ribosyl)ation of nuclear proteins by PARP-1 converts DNA harm into intracellular indicators that activate both DNA restore by the base-excision pathway or cell dying. A household of 18 PARPs has been recognized, however solely essentially the most considerable, PARP-1 and PARP-2, that are each nuclear enzymes, are activated by DNA harm. PARP inhibitors of ever-increasing efficiency have been developed within the 40 years for the reason that discovery of PARP-1, each as instruments for the investigation of PARP-1 operate and as potential modulators of DNA-repair-mediated resistance to cytotoxic remedy.
Owing to the excessive stage of homology between the catalytic domains of PARP-1 and PARP-2, the inhibitors most likely have an effect on each enzymes. Convincing biochemical proof, which has been corroborated by genetic manipulation of PARP-1 exercise, reveals that PARP inhibition is related to elevated sensitivity to DNA-alkylating brokers, topoisomerase I poisons and ionising radiation. Novel PARP inhibitors of ample efficiency and appropriate pharmacokinetic properties to permit analysis in animal fashions have been proven to boost the antitumour exercise of temozolomide (a DNA-methylating agent), topoisomerase poisons and ionising radiation; certainly, the mixture with temozolomide resulted in full tumour regression in two unbiased research.
, Antibody) Cancer Antigen 19-9 (CA 19-9), Antibody |
|
GWB-B599CB |
GenWay Biotech |
1 mg |
Ask for price |
 Cancer Antigen 19-9 Protein |
|
GWB-A828C9 |
GenWay Biotech |
10000 Unit |
Ask for price |
) Cancer Antigen 19-9 Antigen (Liver Carcinoma) |
|
VAng-Cr3873-10kU |
Creative Biolabs |
10 kU |
EUR 472.8 |
|
Description: Cancer Antigen 19-9 Antigen, Host/Source: Liver Carcinoma. The purity is detected by gel filtration and ion-exchange chromatography. It is tested negative for HBsAg, antibodies to HCV and HIV 1/2. |
 Standard Grade) Cancer Antigen 19-9 (CA 19-9) Standard Grade |
|
GWB-1CA918 |
GenWay Biotech |
50000 Unit |
Ask for price |
|
|
Cancer Antigen 19-9 (CA 19-9) Standard Grade |
|
GWB-EECE0C |
GenWay Biotech |
50000 Unit |
Ask for price |
 Antibody) Cancer Antigen 19-9 (CA19-9) Antibody |
|
E63C01201 |
EnoGene |
100μg/100μl |
EUR 225 |
|
Description: Available in various conjugation types. |
 19-9 ELISA) Cancer Antigen (CA) 19-9 ELISA |
|
GWB-BQK048 |
GenWay Biotech |
96 Well Plate |
Ask for price |
 Cancer Antigen CA 19-9 Antibody |
|
abx023798-1mg |
Abbexa |
1 mg |
EUR 1053.6 |
|
|
 Rat Cancer Antigen 19-9, CA 19-9 GENLISA ELISA |
|
KLR1827 |
Krishgen |
1 x 96 wells |
EUR 341 |
 (> 90%)) Cancer Antigen 19-9 Antigen (Liver Carcinoma) (> 90%) |
|
VAng-Cr3875-25kU |
Creative Biolabs |
25 kU |
EUR 885.6 |
|
Description: Cancer Antigen 19-9 Antigen, Host/Source: Liver Carcinoma. The purity is> 90% by SDS-PAGE. It is tested negative for HBsAg, antibodies to HCV and HIV 1/2. |
 Antibody-HRP) Cancer Antigen 19-9 (CA19-9) Antibody-HRP |
|
E63C01202 |
EnoGene |
100μg/100μl |
EUR 295 |
|
Description: Available in various conjugation types. |
, antigen grade) Gastrointestinal Cancer Antigen (CA 19-9), antigen grade |
|
CA1991-N-10 |
Alpha Diagnostics |
10 KU |
EUR 634.8 |
 Antibody-BIOTIN) Cancer Antigen 19-9 (CA19-9) Antibody-BIOTIN |
|
E63C01203 |
EnoGene |
100μg/100μl |
EUR 295 |
|
Description: Available in various conjugation types. |
 High Purity Iodination Grade) Cancer Antigen 19-9 (CA 19-9) High Purity Iodination Grade |
|
GWB-453206 |
GenWay Biotech |
50000 Unit |
Ask for price |
|
|
 (High purity)) Cancer Antigen 19-9 Antigen (Liver Carcinoma) (High purity) |
|
VAng-Cr3874-25kU |
Creative Biolabs |
25 kU |
EUR 1033.2 |
|
Description: Cancer Antigen 19-9 Antigen, Host/Source: Liver Carcinoma. |
) Cancer Antigen CA 19-9 Antigen (Human metastatic liver carcinoma) |
|
VAng-Wyb8635-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: CA 19-9 (Gastrointestinal Cancer), Antigen Grade, Cancer antigen from Human metastatic liver carcinoma, 2900.0 kIU/mL. |
-19-9) Mouse Monoclonal anti-human Cancer Antigen (CA)-19-9 |
|
hAP-1125 |
Angio Proteomie |
50ug |
EUR 400 |
) Cancer Antigen CA 19-9 Antigen (Human adenocarcinoma cell line supernatant) |
|
VAng-Wyb8634-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: CA 19-9 (Gastrointestinal Cancer), Antigen Grade, Cancer antigen from Human adenocarcinoma cell line supernatant, 42,097 Units/mL. |
 Cancer Antigen CA19-9 Antibody |
|
abx020532-1mg |
Abbexa |
1 mg |
EUR 1296 |
|
|
Cancer Antigen CA19-9 Antibody |
|
abx020533-1mg |
Abbexa |
1 mg |
EUR 718.8 |
|
|
Cancer Antigen CA19-9 Antibody |
|
abx020534-1mg |
Abbexa |
1 mg |
EUR 718.8 |
|
|
Cancer Antigen CA19-9 Antibody |
|
abx020535-1mg |
Abbexa |
1 mg |
EUR 718.8 |
|
|
 (Gastrointestinal Cancer)) Cancer Antigen Antibody (CA19-9) (Gastrointestinal Cancer) |
|
GWB-T00219 |
GenWay Biotech |
1 mg |
Ask for price |
 Cancer Antigen 242 Antigen |
|
VAng-Cr3876-10kU |
Creative Biolabs |
10 kU |
EUR 505.2 |
|
Description: Cancer Antigen 242 Antigen, Host/Source: Metastatic Liver. The purity is detected by gel filtration. |
 Cancer Antigen 50 Antigen |
|
VAng-Cr3877-50kU |
Creative Biolabs |
50 kU |
EUR 6642 |
|
Description: Cancer Antigen 50 Antigen, Host/Source: Human Cell Culture. It is tested negative for HBsAg, antibodies to HCV and HIV 1/2. |
 IgG # 1, aff pure) Monoclonal Anti-Human Cancer Antigen 19-9 (CA199 or CA19-9) IgG # 1, aff pure |
|
CA1991-M |
Alpha Diagnostics |
1 mg |
EUR 854.4 |
 Cancer Antigen 72-4 Antigen |
|
VAng-Cr3878-10kU |
Creative Biolabs |
10 kU |
EUR 505.2 |
|
Description: Cancer Antigen 72-4 Antigen, Host/Source: Metastatic Liver. The purity is ~65% by SDS-PAGE. It is tested negative for HBsAg, antibodies to HCV and HIV 1/2. |
) Cancer Antigen 125 Antigen (Ascites Fluid) |
|
VAng-Cr3870-10kU |
Creative Biolabs |
10 kU |
EUR 1132.8 |
|
Description: Cancer Antigen 125 Antigen, Host/Source: Ascites Fluid. The purity is ≥ 95% by SDS-PAGE. |
) Cancer Antigen CEA Antigen (Human Fluids) |
|
VAng-Wyb8644-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Carcinoembryonic Antigen, Calibrator Grade, Cancer antigen from Human Fluids, 1.13 mg/mL. |
 Cancer Antigen CA19-9 Enzyme Immunoassay Test Kit |
|
GWB-EED29A |
GenWay Biotech |
ELISA_Kits |
Ask for price |
) Cancer Antigen 125 Antigen (Human Adenocarcinoma) |
|
VAng-Cr3868-10kU |
Creative Biolabs |
10 kU |
EUR 505.2 |
|
Description: Cancer Antigen 125 Antigen, Host/Source: Human Adenocarcinoma. The purity is detected by salt extraction and chromatography. |
 Human Cancer Antigen CA15-3 Antigen Grade |
|
GWB-C54ECC |
GenWay Biotech |
50000 Unit |
Ask for price |
) Cancer Antigen AFP Antigen (Human Cord Blood) |
|
VAng-Wyb8624-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Alpha Fetoprotein (66 kDa), Cancer antigen from Human Cord Blood, 1.73 mg/mL. |
 Cancer antigen 15-3, Antibody |
|
GWB-C9AE54 |
GenWay Biotech |
1 mg |
Ask for price |
) Cancer Antigen CA-125 Antigen (Human Fluids) |
|
VAng-Wyb8639-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: CA-125, Calibrator Grade, cancer antigen from Human Fluids, 53.26 KU/mL. |
 Protein) Human Cancer Antigen CA125 (Ovarian Cancer) Protein |
|
abx061590-100kU |
Abbexa |
100 kU |
EUR 1446 |
|
|
Human Cancer Antigen CA125 (Ovarian Cancer) Protein |
|
abx061590-100g |
Abbexa |
100 µg |
Ask for price |
Human Cancer Antigen CA125 (Ovarian Cancer) Protein |
|
abx061590-10g |
Abbexa |
10 µg |
EUR 1537.5 |
Human Cancer Antigen CA125 (Ovarian Cancer) Protein |
|
abx061590-50g |
Abbexa |
50 µg |
Ask for price |
 (> 90%)) Cancer Antigen 125 Antigen (Human Adenocarcinoma) (> 90%) |
|
VAng-Cr3869-25kU |
Creative Biolabs |
25 kU |
EUR 967.2 |
|
Description: Cancer Antigen 125 Antigen, Host/Source: Human Adenocarcinoma. The purity is> 90% by SDS-PAGE. Matched Pair: HM183, HM184, HM185, HM186. |
 Antibody) Cancer Antigen 125 (CA125) Antibody |
|
E63C01601 |
EnoGene |
100μg/100μl |
EUR 225 |
|
Description: Available in various conjugation types. |
) Cancer Antigen CEA Antigen (Human Metastatic Liver) |
|
VAng-Wyb8645-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Carcinoembryonic Antigen, Antigen Grade, Cancer antigen from Human Metastatic Liver, 5.5 mg/mL. |
, Antibody) Cancer Antigen 125 (CA 125), Antibody |
|
GWB-2F8B7C |
GenWay Biotech |
1 mg |
Ask for price |
|
|
Cancer Antigen 125 (CA 125), Antibody |
|
GWB-10B890 |
GenWay Biotech |
1 mg |
Ask for price |
|
|
Cancer Antigen 125 (CA 125), Antibody |
|
GWB-484850 |
GenWay Biotech |
1 mg |
Ask for price |
|
|
Cancer Antigen 125 (CA 125), Antibody |
|
GWB-A64DAC |
GenWay Biotech |
1 mg |
Ask for price |
Cancer Antigen 125 (CA 125), Antibody |
|
GWB-9D1541 |
GenWay Biotech |
1 mg |
Ask for price |
Cancer Antigen 125 (CA 125), Antibody |
|
GWB-85FE2C |
GenWay Biotech |
1 mg |
Ask for price |
Cancer Antigen 125 (CA 125), Antibody |
|
GWB-6D5E80 |
GenWay Biotech |
1 mg |
Ask for price |
Cancer Antigen 125 (CA 125), Antibody |
|
GWB-F984F6 |
GenWay Biotech |
1 mg |
Ask for price |
) Cancer Antigen 15-3 MUC 1 Antigen (Human Milk) |
|
VAng-Cr3871-10kU |
Creative Biolabs |
10 kU |
EUR 505.2 |
|
Description: Cancer Antigen 15-3 MUC 1 Antigen, Host/Source: Human Milk. The purity is detected by salt extraction and delipidization following high speed centrifugation. It is tested negative for HBsAg, antibodies to HCV and HIV 1/2. |
 15-3 ELISA) Cancer Antigen (CA) 15-3 ELISA |
|
GWB-BQK041 |
GenWay Biotech |
96 Well Plate |
Ask for price |
) Cancer Antigen CA-125 Antigen (Human Adenocarcinoma) |
|
VAng-Wyb8642-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: CA-125, Calibrator Grade, Cancer antigen from Human Adenocarcinoma, 500 kIU / mL. |
) Cancer Antigen AFP Antigen (Human hepatocellular carcinoma) |
|
VAng-Wyb8625-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Alpha Fetoprotein, Antigen Grade, Cancer antigen from human hepatocellular carcinoma, 2.93 mg/mL. |
 Rat cancer antigen 27-29 ELISA kit |
|
E02C1276-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rat cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat cancer antigen 27-29 ELISA kit |
|
E02C1276-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rat cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat cancer antigen 27-29 ELISA kit |
|
E02C1276-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rat cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Dog cancer antigen 27-29 ELISA kit |
|
E08C1276-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Canine cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog cancer antigen 27-29 ELISA kit |
|
E08C1276-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Canine cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog cancer antigen 27-29 ELISA kit |
|
E08C1276-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Canine cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Pig cancer antigen 27-29 ELISA kit |
|
E07C1276-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Porcine cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig cancer antigen 27-29 ELISA kit |
|
E07C1276-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Porcine cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig cancer antigen 27-29 ELISA kit |
|
E07C1276-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Porcine cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Rat cancer antigen 27-29 ELISA Kit |
|
E01A11532 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Protein) Human Cancer Antigen 125 (CA125) Protein |
|
abx061598-250kU |
Abbexa |
250 kU |
EUR 1195.2 |
|
|
Human Cancer Antigen 125 (CA125) Protein |
|
abx061598-1mg |
Abbexa |
1 mg |
EUR 1062.5 |
Human Cancer Antigen 125 (CA125) Protein |
|
abx061598-5mg |
Abbexa |
5 mg |
Ask for price |
 Antibody-HRP) Cancer Antigen 125 (CA125) Antibody-HRP |
|
E63C01602 |
EnoGene |
100μg/100μl |
EUR 275 |
|
Description: Available in various conjugation types. |
 Goat cancer antigen 27-29 ELISA Kit |
|
E01A46444 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Goat cancer antigen 27-29 ELISA kit |
|
E06C1276-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Goat cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat cancer antigen 27-29 ELISA kit |
|
E06C1276-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Goat cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat cancer antigen 27-29 ELISA kit |
|
E06C1276-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Goat cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 High Purity) Cancer Antigen 125 (CA 125) High Purity |
|
GWB-B446E0 |
GenWay Biotech |
50000 Unit |
Ask for price |
 -HRP, Antibody) Cancer Antigen 125 (CA 125) -HRP, Antibody |
|
GWB-D528AD |
GenWay Biotech |
0.5 mg |
Ask for price |
 Canine cancer antigen 27-29 ELISA Kit |
|
E01A63877 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Human cancer antigen 27-29 ELISA Kit |
|
E01A2772 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Mouse cancer antigen 27-29 ELISA Kit |
|
E01A20273 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Mouse cancer antigen 27-29 ELISA kit |
|
E03C1276-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse cancer antigen 27-29 ELISA kit |
|
E03C1276-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse cancer antigen 27-29 ELISA kit |
|
E03C1276-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Mouse cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Sheep cancer antigen 27-29 ELISA Kit |
|
E01A98738 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Human cancer antigen 27-29 ELISA kit |
|
E01C1276-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Human cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human cancer antigen 27-29 ELISA kit |
|
E01C1276-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Human cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human cancer antigen 27-29 ELISA kit |
|
E01C1276-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Human cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
, Antibody) Cancer Antigen 50 (CA 50), Antibody |
|
GWB-737484 |
GenWay Biotech |
1 mg |
Ask for price |
) Cancer Antigen 15-3 MUC 1 Antigen (Human Ascites Fluid) |
|
VAng-Cr3872-10kU |
Creative Biolabs |
10 kU |
EUR 1363.2 |
|
Description: Cancer Antigen 15-3 MUC 1 Antigen, Host/Source: Human Ascites Fluid. |
 Rabbit cancer antigen 27-29 ELISA Kit |
|
E01A29012 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Rabbit cancer antigen 27-29 ELISA kit |
|
E04C1276-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rabbit cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit cancer antigen 27-29 ELISA kit |
|
E04C1276-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rabbit cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit cancer antigen 27-29 ELISA kit |
|
E04C1276-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rabbit cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Monkey cancer antigen 27-29 ELISA Kit |
|
E01A72590 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Bovine cancer antigen 27-29 ELISA Kit |
|
E01A81309 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Monkey cancer antigen 27-29 ELISA kit |
|
E09C1276-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey cancer antigen 27-29 ELISA kit |
|
E09C1276-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Monkey cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey cancer antigen 27-29 ELISA kit |
|
E09C1276-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
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Description: A sandwich ELISA for quantitative measurement of Monkey cancer antigen 27-29 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Antibody-BIOTIN) Cancer Antigen 125 (CA125) Antibody-BIOTIN |
|
E63C01603 |
EnoGene |
100μg/100μl |
EUR 275 |
|
Description: Available in various conjugation types. |
 (1.5 mg/ml)) Cancer Antigen AFP Antigen (Human Cord Serum) (1.5 mg/ml) |
|
VAng-Wyb8627-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Alpha Fetoprotein, Antigen Grade, Cancer antigen from Human Cord Serum, 1.5 mg/ml. |
 Porcine cancer antigen 27-29 ELISA Kit |
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E01A55161 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Chicken cancer antigen 27-29 ELISA Kit |
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E01A90032 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
 Standard Grade) Cancer Antigen 125 (CA 125) Standard Grade |
|
GWB-565817 |
GenWay Biotech |
25000 Unit |
Ask for price |
|
|
Cancer Antigen 125 (CA 125) Standard Grade |
|
GWB-A9985A |
GenWay Biotech |
50000 Unit |
Ask for price |
 -BIOTIN, Antibody) Cancer Antigen 125 (CA 125) -BIOTIN, Antibody |
|
GWB-19E050 |
GenWay Biotech |
1 mg |
Ask for price |
|
|
 Rat Colon Cancer Antigen ELISA kit |
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E01A11103 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Rat Colon Cancer Antigen ELISA kit |
|
E02C0703-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
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Description: A competitive ELISA for quantitative measurement of Rat Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Colon Cancer Antigen ELISA kit |
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E02C0703-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Colon Cancer Antigen ELISA kit |
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E02C0703-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Dog Colon Cancer Antigen ELISA kit |
|
E08C0703-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Canine Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Colon Cancer Antigen ELISA kit |
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E08C0703-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
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Description: A competitive ELISA for quantitative measurement of Canine Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog Colon Cancer Antigen ELISA kit |
|
E08C0703-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Canine Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Pig Colon Cancer Antigen ELISA kit |
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E07C0703-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
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Description: A competitive ELISA for quantitative measurement of Porcine Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Colon Cancer Antigen ELISA kit |
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E07C0703-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Porcine Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig Colon Cancer Antigen ELISA kit |
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E07C0703-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Porcine Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Antibody) Cancer Antigen 24-2 (CA24-2) Antibody |
|
E63C01301 |
EnoGene |
100μg/100μl |
EUR 225 |
|
Description: Available in various conjugation types. |
 Antibody) Cancer Antigen 15-3 (CA15-3) Antibody |
|
abx023568-400l |
Abbexa |
400 µl |
Ask for price |
Cancer Antigen 15-3 (CA15-3) Antibody |
|
abx023568-80l |
Abbexa |
80 µl |
EUR 900 |
Cancer Antigen 15-3 (CA15-3) Antibody |
|
abx342029-100l |
Abbexa |
100 µl |
Ask for price |
Cancer Antigen 15-3 (CA15-3) Antibody |
|
abx342029-50l |
Abbexa |
50 µl |
EUR 2575 |
 (1.0 mg/Vial)) Cancer Antigen AFP Antigen (Human Cord Serum) (1.0 mg/Vial) |
|
VAng-Wyb8626-inquire |
Creative Biolabs |
inquire |
Ask for price |
|
Description: Alpha Fetoprotein, Antigen Grade, Cancer antigen from Human Cord Serum, 1.0 mg/Vial. |
 Goat Colon Cancer Antigen ELISA kit |
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E01A46016 |
BlueGene |
96T |
EUR 700 |
|
Description: ELISA |
Goat Colon Cancer Antigen ELISA kit |
|
E06C0703-192T |
BlueGene |
192 tests |
EUR 1524 |
|
|
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Description: A competitive ELISA for quantitative measurement of Goat Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Colon Cancer Antigen ELISA kit |
|
E06C0703-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Goat Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat Colon Cancer Antigen ELISA kit |
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E06C0703-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Goat Colon Cancer Antigen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Calibrator Grade Protein) Cancer Antigen CA242 (Gastrointestinal Cancer) Calibrator Grade Protein |
|
GWB-T00229 |
GenWay Biotech |
50KU |
Ask for price |
The mixture of a PARP inhibitor and temozolomide is at present present process scientific analysis for the primary time. Preclinical and preliminary scientific proof, nonetheless, suggests a probably broader scope for PARP inhibitors. Lack of operate of assorted proteins concerned in double strand break restore aside from BRCA1/2 has been urged to be synthetically deadly with PARP inhibition. Inactivation of those genes has been reported in a subset of human cancers and would possibly subsequently represent predictive biomarkers for PARP inhibition. Right here we focus on the proof that the scientific use of PARP inhibition could also be broader than focusing on of cancers in BRCA1/2 germ-line mutation carriers.
