Poly (ADP-ribose) Polymerase (PARP) has a well-established function in DNA restore processes, and small molecule inhibitors of PARP have been developed as chemotherapy sensitisers for […]
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
Whereas target-specific medication can be found for treating ERBB2-overexpressing and hormone receptor-positive breast cancers, no tailor-made remedy exists for hormone receptor- and ERBB2-negative (“triple-negative”) mammary […]